Delayed-rectifier potassium channel regulatory subunit KCNS3
Also known as: KCNS3
Function
Potassium channel regulatory subunit that modulates the delayed rectifier potassium channel activity of KCNB1 by namely slowing down the deactivation and inactivation time constants. While it does not form functional channel on its own, it can form functional heterotetrameric channels with KCNB1.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- DNA-Binding Transcriptional Regulators & related
Gene Ontology · 11
- GO:0005829 cytosol
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0005251 delayed rectifier potassium channel activity
- GO:0015459 potassium channel regulator activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
- GO:1901379 regulation of potassium ion transmembrane transport
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Delayed-rectifier potassium channel regulatory subunit KCNS3 1.00
- Delayed-rectifier potassium channel regulatory subunit KCNS3 0.99
- Delayed-rectifier potassium channel regulatory subunit KCNS3 0.99
- Delayed-rectifier potassium channel regulatory subunit KCNS2 0.90
- Delayed-rectifier potassium channel regulatory subunit KCNS2 0.90
- Delayed-rectifier potassium channel regulatory subunit KCNS2 0.90
- Voltage-gated potassium channel regulatory subunit KCNF1 0.88
- Voltage-gated potassium channel regulatory subunit KCNF1 0.88
- Voltage-gated potassium channel regulatory subunit KCNF1 0.87
- Potassium voltage-gated channel subfamily V member 1 0.83
- Voltage-gated potassium channel regulatory subunit KCNG2 0.83
- Potassium voltage-gated channel subfamily V member 1 0.82
Co-cited proteins · studied together in the literature
- Delayed-rectifier potassium channel regulatory subunit KCNS1 1 shared papers
- Potassium voltage-gated channel subfamily B member 1 1 shared papers
Literature · 5 cited papers
- Expression of an electrically silent voltage-gated potassium channel in the human placenta. J. Obstet. Gynaecol. · 2012
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Electrically silent potassium channel subunits from human lens epithelium. Am. J. Physiol. · 1999
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