Voltage-gated potassium channel regulatory subunit KCNF1

UniProt Q9H3M0 Organism Homo sapiens Gene KCNF1

Also known as: KCNF1

Function

Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone.

Classification

Family (Pfam): PF02214 BTB_2, PF00520 Ion_trans
InterPro: Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, KCNF1-like_BTB_POZ, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Cytochrome P450 & Heme Enzymes

Gene Ontology · 12

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-gated potassium channel regulatory subunit KCNG1 1 shared papers

Literature · 3 cited papers

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Isolation, characterization, and mapping of two human potassium channels. Biochem. Biophys. Res. Commun. · 1997

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