Troponin T, cardiac muscle

Function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Classification

Family (Pfam)

PF00992 Troponin

InterPro

TNNT, Troponin, Troponin_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 25

• 1J1D X-ray 2.61A
• 1J1E X-ray 3.30A
• 4Y99 X-ray 2.00A
• 6KN7 EM 6.60A
• 6KN8 EM 4.80A
• 7UTI EM 4.80A
• 7UTL EM 6.60A
• 8FMM X-ray 3.11A
• 8FMN X-ray 3.10A
• 8FMO X-ray 2.61A
• 8FMP X-ray 3.24A
• 8FMQ X-ray 3.25A
• … and 13 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0097512 cardiac myofibril
• GO:1990584 cardiac Troponin complex
• GO:0005829 cytosol
• GO:0030017 sarcomere
• GO:0005865 striated muscle thin filament
• GO:0005861 troponin complex
• GO:0003779 actin binding
• GO:0042802 identical protein binding
• GO:0005523 tropomyosin binding
• GO:0030172 troponin C binding
• GO:0031013 troponin I binding
• GO:0060048 cardiac muscle contraction
• GO:0030049 muscle filament sliding
• GO:0032780 negative regulation of ATP-dependent activity
• GO:0032781 positive regulation of ATP-dependent activity
• GO:0008016 regulation of heart contraction
• GO:0006937 regulation of muscle contraction
• GO:0051592 response to calcium ion
• GO:0045214 sarcomere organization
• GO:0055010 ventricular cardiac muscle tissue morphogenesis

Disease associations

• hypertrophic cardiomyopathy 2 MONDO:0007266
• dilated cardiomyopathy 1D MONDO:0011095
• cardiomyopathy, familial restrictive, 3 MONDO:0012900

Drugs targeting this protein · 1

• LEVOSIMENDAN positive modulator

Related proteins · sequence + function similarity

• Troponin T, cardiac muscle 0.99
• Troponin T, cardiac muscle 0.98
• Troponin T, cardiac muscle 0.98
• Troponin T, cardiac muscle 0.98
• Troponin T, cardiac muscle 0.96
• Troponin T, cardiac muscle isoforms 0.96
• Troponin T, fast skeletal muscle 0.95
• Troponin T, fast skeletal muscle 0.95
• Troponin T, slow skeletal muscle 0.95
• Troponin T, slow skeletal muscle 0.95
• Troponin T, slow skeletal muscle 0.95
• Troponin T, slow skeletal muscle 0.95

Co-cited proteins · studied together in the literature

• Tropomyosin alpha-1 chain 3 shared papers
• Myosin-7 7 shared papers
• Troponin C, slow skeletal and cardiac muscles 1 shared papers
• Myosin-binding protein C, cardiac-type 4 shared papers
• Troponin I, cardiac muscle 4 shared papers
• Myosin light chain 3 2 shared papers
• Myosin regulatory light chain 2, ventricular/cardiac muscle isoform 2 shared papers
• Fatty acid-binding protein, heart 1 shared papers
• RNA-binding protein 20 1 shared papers
• Prelamin-A/C 1 shared papers
• Superoxide dismutase [Mn], mitochondrial 1 shared papers
• Cytochrome c oxidase subunit 5A, mitochondrial 1 shared papers

Literature · 29 cited papers

• Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy. Eur. J. Med. Genet. · 2011
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene. Pediatrics · 2006
• Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling. J. Med. Genet. · 2005
• Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene. Eur. Heart J. · 2005
• Mutations profile in Chinese patients with hypertrophic cardiomyopathy. Clin. Chim. Acta · 2005
• Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy. Clin. Genet. · 2003
• Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form. Nature · 2003
• Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation · 2003
• … and 17 more in the literature graph