Myosin light chain 3

Function

Regulatory light chain of myosin. Does not bind calcium.

Classification

InterPro

CALM/Myosin/TropC-like, EF-hand-dom_pair, EF_hand_dom

Functional cluster

Adenylate Kinases & Peroxiredoxins

Experimental structures · PDB · 3

• 5TBY EM 20.00A
• 8ACT EM 3.60A
• 8G4L EM 6.40A

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0031672 A band
• GO:0005829 cytosol
• GO:0031674 I band
• GO:0005859 muscle myosin complex
• GO:0016460 myosin II complex
• GO:0030017 sarcomere
• GO:0003785 actin monomer binding
• GO:0005509 calcium ion binding
• GO:0003774 cytoskeletal motor activity
• GO:0032038 myosin II heavy chain binding
• GO:0008307 structural constituent of muscle
• GO:0060048 cardiac muscle contraction
• GO:0006936 muscle contraction
• GO:0006942 regulation of striated muscle contraction
• GO:0002026 regulation of the force of heart contraction
• GO:0007519 skeletal muscle tissue development
• GO:0055010 ventricular cardiac muscle tissue morphogenesis

Disease associations

• hypertrophic cardiomyopathy 8 MONDO:0012111

Drugs targeting this protein · 3

• OMECAMTIV MECARBIL activator
• MAVACAMTEN inhibitor
• DANICAMTIV activator

Related proteins · sequence + function similarity

• Myosin light chain 3 1.00
• Myosin light chain 3 0.98
• Myosin light chain 3 0.98
• Myosin light chain 1, cardiac muscle 0.98
• Myosin light chain 3 0.98
• Myosin light chain 4 0.97
• Myosin light chain 4 0.97
• Myosin light chain 4 0.96
• Myosin light chain 4 0.96
• Myosin light chain, embryonic 0.95
• Myosin light chain 1/3, skeletal muscle isoform 0.93
• Myosin light chain 1/3, skeletal muscle isoform 0.92

Co-cited proteins · studied together in the literature

• Myosin light chain 4 1 shared papers
• Myosin regulatory light chain 2, ventricular/cardiac muscle isoform 3 shared papers
• Myosin light chain 3 1 shared papers
• Myosin regulatory light chain 2, ventricular/cardiac muscle isoform 1 shared papers
• Myosin regulatory light chain 11 1 shared papers
• Myosin regulatory light chain 11 1 shared papers
• Fatty acid-binding protein, heart 1 shared papers
• Myosin light chain 1, skeletal muscle isoform 1 shared papers
• Troponin T, cardiac muscle 2 shared papers
• Troponin I, cardiac muscle 1 shared papers
• Myosin-binding protein C, cardiac-type 1 shared papers
• Superoxide dismutase [Mn], mitochondrial 1 shared papers

Literature · 11 cited papers

• Infantile hypertrophic cardiomyopathy associated with a novel MYL3 mutation. Cardiology · 2013
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy. Circulation · 2003
• Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology. Circulation · 2002
• Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle. Nat. Genet. · 1996
• The major protein expression profile and two-dimensional protein database of human heart. Electrophoresis · 1995
• The widespread distribution of alpha-N-trimethylalanine as the N-terminal amino acid of light chains from vertebrate striated muscle myosins. Eur. J. Biochem. · 1985
• Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. J. Biol. Chem. · 1988
• Molecular cloning and complete nucleotide sequence of a human ventricular myosin light chain 1. Nucleic Acids Res. · 1988
• Human ventricular/slow twitch myosin alkali light chain gene characterization, sequence, and chromosomal location. J. Biol. Chem. · 1989