Myosin light chain 4

Function

Regulatory light chain of myosin. Does not bind calcium.

Classification

InterPro

CALM/Myosin/TropC-like, EF-hand-dom_pair, EF_hand_dom

Functional cluster

Adenylate Kinases & Peroxiredoxins

Gene Ontology · 10

• GO:0031672 A band
• GO:0005829 cytosol
• GO:0016460 myosin II complex
• GO:0051015 actin filament binding
• GO:0003785 actin monomer binding
• GO:0005509 calcium ion binding
• GO:0032038 myosin II heavy chain binding
• GO:0060048 cardiac muscle contraction
• GO:0006936 muscle contraction
• GO:0002026 regulation of the force of heart contraction

Disease associations

• atrial fibrillation, familial, 18 MONDO:0015001

Drugs targeting this protein · 3

• OMECAMTIV MECARBIL activator
• MAVACAMTEN inhibitor
• DANICAMTIV activator

Related proteins · sequence + function similarity

• Myosin light chain 4 0.99
• Myosin light chain 3 0.98
• Myosin light chain 3 0.98
• Myosin light chain 1, cardiac muscle 0.97
• Myosin light chain 3 0.97
• Myosin light chain 4 0.97
• Myosin light chain 4 0.97
• Myosin light chain 3 0.97
• Myosin light chain 3 0.97
• Myosin light chain 1/3, skeletal muscle isoform 0.95
• Myosin light chain 1/3, skeletal muscle isoform 0.94
• Myosin light chain 1/3, skeletal muscle isoform 0.94

Co-cited proteins · studied together in the literature

• Myosin light chain 1/3, skeletal muscle isoform 1 shared papers
• Myosin light chain 3 1 shared papers

Literature · 9 cited papers

• A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat. Commun. · 2016
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones. J. Biol. Chem. · 1988
• A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria. Eur. J. Biochem. · 1988
• Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. Gene · 1988
• Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells. J. Mol. Biol. · 1990
• Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location. Genomics · 1990
• The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions. Nucleic Acids Res. · 1991