Troponin T, fast skeletal muscle

Function

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Classification

Family (Pfam)

PF00992 Troponin

InterPro

TNNT, Troponin, Troponin_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Gene Ontology · 11

• GO:0005829 cytosol
• GO:0005861 troponin complex
• GO:0048306 calcium-dependent protein binding
• GO:0005523 tropomyosin binding
• GO:0030172 troponin C binding
• GO:0031013 troponin I binding
• GO:1903612 positive regulation of calcium-dependent ATPase activity
• GO:0043462 regulation of ATP-dependent activity
• GO:0006942 regulation of striated muscle contraction
• GO:0045214 sarcomere organization
• GO:0003009 skeletal muscle contraction

Disease associations

• arthrogryposis, distal, type 2B2 MONDO:0032750

Drugs targeting this protein · 2

• TIRASEMTIV activator
• RELDESEMTIV activator

Related proteins · sequence + function similarity

• Troponin T, fast skeletal muscle 0.99
• Troponin T, fast skeletal muscle isoforms 0.99
• Troponin T, fast skeletal muscle 0.98
• Troponin T, fast skeletal muscle 0.98
• Troponin T, fast skeletal muscle 0.98
• Troponin T, fast skeletal muscle isoforms 0.98
• Troponin T, fast skeletal muscle 0.98
• Troponin T, cardiac muscle 0.96
• Troponin T, cardiac muscle 0.96
• Troponin T, cardiac muscle 0.95
• Troponin T, cardiac muscle 0.95
• Troponin T, slow skeletal muscle 0.95

Literature · 10 cited papers

• Exome sequencing identifies a dominant TNNT3 mutation in a large family with distal arthrogryposis. Mol. Syndromol. · 2014
• A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus. Eur. J. Med. Genet. · 2011
• Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. Clin. Orthop. Relat. Res. · 2009
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B. Am. J. Hum. Genet. · 2003
• Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family. DNA Cell Biol. · 1994
• Identification of a fetal exon in the human fast troponin T gene. FEBS Lett. · 1994