Troponin C, slow skeletal and cardiac muscles

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Classification

Family (Pfam)

PF13499 EF-hand_7, PF13833 EF-hand_8

InterPro

CALM/Myosin/TropC-like, EF-hand-dom_pair, EF_Hand_1_Ca_BS, EF_hand_dom

Functional cluster

Ribosomal Protein L12 & Acyl Carriers

Experimental structures · PDB · 61

• 1AP4 NMR
• 1IH0 NMR
• 1J1D X-ray 2.61A
• 1J1E X-ray 3.30A
• 1LXF NMR
• 1MXL NMR
• 1OZS NMR
• 1SPY NMR
• 1WRK X-ray 2.15A
• 1WRL X-ray 2.60A
• 2JT0 NMR
• 2JT3 NMR
• … and 49 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:1990584 cardiac Troponin complex
• GO:0005829 cytosol
• GO:0030017 sarcomere
• GO:0005861 troponin complex
• GO:0051015 actin filament binding
• GO:0005509 calcium ion binding
• GO:0048306 calcium-dependent protein binding
• GO:0042803 protein homodimerization activity
• GO:0031013 troponin I binding
• GO:0031014 troponin T binding
• GO:0086003 cardiac muscle cell contraction
• GO:0060048 cardiac muscle contraction
• GO:0002086 diaphragm contraction
• GO:0030049 muscle filament sliding
• GO:0032780 negative regulation of ATP-dependent activity
• GO:0006937 regulation of muscle contraction
• GO:0032972 regulation of muscle filament sliding speed
• GO:0010038 response to metal ion
• GO:0003009 skeletal muscle contraction
• GO:0055010 ventricular cardiac muscle tissue morphogenesis

Disease associations

• dilated cardiomyopathy 1Z MONDO:0012745
• hypertrophic cardiomyopathy 13 MONDO:0013195

Drugs targeting this protein · 1

• LEVOSIMENDAN positive modulator

Related proteins · sequence + function similarity

• Troponin C, slow skeletal and cardiac muscles 1.00
• Troponin C, slow skeletal and cardiac muscles 1.00
• Troponin C, slow skeletal and cardiac muscles 1.00
• Troponin C, slow skeletal and cardiac muscles 1.00
• Troponin C, slow skeletal and cardiac muscles 1.00
• Troponin C, slow skeletal and cardiac muscles 0.99
• Troponin C, skeletal muscle 0.96
• Troponin C, skeletal muscle 0.96
• Troponin C, skeletal muscle 0.95
• Troponin C, skeletal muscle 0.95
• Troponin C, skeletal muscle 0.95
• Troponin C, skeletal muscle 0.95

Co-cited proteins · studied together in the literature

• Troponin C, skeletal muscle 1 shared papers
• Troponin T, cardiac muscle 1 shared papers

Literature · 12 cited papers

• A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy. J. Biol. Chem. · 2009
• Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C. J. Mol. Cell. Cardiol. · 2008
• Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C. FEBS J. · 2005
• Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I. J. Biol. Chem. · 2003
• First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy. Hum. Mutat. · 2001
• Calcium-induced structural transition in the regulatory domain of human cardiac troponin C. Biochemistry · 1997
• Structural and functional domains of the troponin complex revealed by limited digestion. Eur. J. Biochem. · 1997
• The amino acid sequence of human cardiac troponin-C. Muscle Nerve · 1986
• Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J. Mol. Biol. · 1988
• Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. J. Biol. Chem. · 1990