Troponin C, skeletal muscle

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Classification

Family (Pfam)

PF13499 EF-hand_7

InterPro

CALM/Myosin/TropC-like, EF-hand-dom_pair, EF_Hand_1_Ca_BS, EF_hand_dom

Functional cluster

Serine/Threonine Protein Kinases

Experimental structures · PDB · 1

• 7KAA NMR

A predicted model is available from AlphaFold.

Gene Ontology · 5

• GO:0005829 cytosol
• GO:0005861 troponin complex
• GO:0005509 calcium ion binding
• GO:0006937 regulation of muscle contraction
• GO:0003009 skeletal muscle contraction

Disease associations

• congenital myopathy 15 MONDO:0859335

Drugs targeting this protein · 2

• TIRASEMTIV activator
• RELDESEMTIV activator

Related proteins · sequence + function similarity

• Troponin C, skeletal muscle 1.00
• Troponin C, skeletal muscle 1.00
• Troponin C, skeletal muscle 0.99
• Troponin C, skeletal muscle 0.99
• Troponin C, skeletal muscle 0.99
• Troponin C, skeletal muscle 0.98
• Troponin C, skeletal muscle 0.98
• Troponin C, slow skeletal and cardiac muscles 0.95
• Troponin C, slow skeletal and cardiac muscles 0.95
• Troponin C, slow skeletal and cardiac muscles 0.95
• Troponin C, slow skeletal and cardiac muscles 0.95
• Troponin C, slow skeletal and cardiac muscles 0.95

Co-cited proteins · studied together in the literature

• Troponin C, slow skeletal and cardiac muscles 1 shared papers

Literature · 7 cited papers

• Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. J. Clin. Invest. · 2021
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J. Mol. Biol. · 1988
• Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. J. Biol. Chem. · 1990
• Human skeletal muscle proteins. The primary structure of troponin C. J. Mol. Evol. · 1976