Myosin-7
Also known as: MYH7, MYHCB
Function
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle.
Classification
- Family (Pfam)
- PF00063 Myosin_head, PF02736 Myosin_N, PF01576 Myosin_tail_1
- InterPro
- IQ_motif_EF-hand-BS, Kinesin_motor_dom_sf, Myosin_head_motor_dom-like, Myosin_S1_N, Myosin_tail, P-loop_NTPase, SH3_Myosin, XRCC4-like_C
- Functional cluster
- Protein Serine/Threonine Kinases
Experimental structures · PDB · 37
- 2FXM X-ray 2.70A
- 2FXO X-ray 2.50A
- 3DTP EM 20.00A
- 4DB1 X-ray 2.60A
- 4P7H X-ray 3.20A
- 4PA0 X-ray 2.25A
- 4XA1 X-ray 3.20A
- 4XA3 X-ray 2.55A
- 4XA4 X-ray 2.33A
- 4XA6 X-ray 3.42A
- 5CHX X-ray 2.30A
- 5CJ0 X-ray 2.30A
- … and 25 more
A predicted model is available from AlphaFold.
Gene Ontology · 25
- GO:0005737 cytoplasm
- GO:0005859 muscle myosin complex
- GO:0030016 myofibril
- GO:0016459 myosin complex
- GO:0032982 myosin filament
- GO:0016460 myosin II complex
- GO:0030017 sarcomere
- GO:0001725 stress fiber
- GO:0030018 Z disc
- GO:0051015 actin filament binding
- GO:0005524 ATP binding
- GO:0005516 calmodulin binding
- GO:0000146 microfilament motor activity
- GO:0007512 adult heart development
- GO:0046034 ATP metabolic process
- GO:0060048 cardiac muscle contraction
- GO:0006936 muscle contraction
- GO:0030049 muscle filament sliding
- GO:0002027 regulation of heart rate
- GO:0031449 regulation of slow-twitch skeletal muscle fiber contraction
- GO:0002026 regulation of the force of heart contraction
- GO:0014728 regulation of the force of skeletal muscle contraction
- GO:0003009 skeletal muscle contraction
- GO:0006941 striated muscle contraction
- GO:0055010 ventricular cardiac muscle tissue morphogenesis
Disease associations
- MYH7-related skeletal myopathy MONDO:0008050
- hypertrophic cardiomyopathy 1 MONDO:0008647
- myopathy, myosin storage, autosomal recessive MONDO:0009708
- congenital myopathy 7A, myosin storage, autosomal dominant MONDO:0008409
- dilated cardiomyopathy 1S MONDO:0013262
Drugs targeting this protein · 3
- OMECAMTIV MECARBIL activator
- MAVACAMTEN inhibitor
- DANICAMTIV activator
Related proteins · sequence + function similarity
Co-cited proteins · studied together in the literature
- Myosin-binding protein C, cardiac-type 9 shared papers
- Myosin-6 3 shared papers
- Troponin T, cardiac muscle 7 shared papers
- Myosin-1 1 shared papers
- Myosin-8 1 shared papers
- Myosin-3 1 shared papers
- Myosin light chain kinase 2, skeletal/cardiac muscle 1 shared papers
- Myosin-7 1 shared papers
- Tropomyosin alpha-1 chain 2 shared papers
- Myosin light chain kinase 2, skeletal/cardiac muscle 1 shared papers
- Troponin I, cardiac muscle 4 shared papers
- Myosin regulatory light chain 2, ventricular/cardiac muscle isoform 2 shared papers
Literature · 89 cited papers
- A composite approach towards a complete model of the myosin rod. Proteins · 2016
- Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity. Nat. Commun. · 2015
- Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc. Natl. Acad. Sci. U.S.A. · 2015
- Homozygous MYH7 R1820W mutation results in recessive myosin storage myopathy: scapuloperoneal and respiratory weakness with dilated cardiomyopathy. Neuromuscul. Disord. · 2015
- Hypertrophic cardiomyopathy: a new mutation illustrates the need for family-centered care. Pediatr. Cardiol. · 2014
- Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy. Eur. J. Med. Genet. · 2011
- Mutations in the sarcomere gene MYH7 in Ebstein anomaly. Circ. Cardiovasc. Genet. · 2011
- Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. Circ. Res. · 2010
- A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. · 2010
- Mutations in sarcomere protein genes in left ventricular noncompaction. Circulation · 2008
- Shared genetic causes of cardiac hypertrophy in children and adults. N. Engl. J. Med. · 2008
- Familial hypertrophic cardiomyopathy associated with cardiac beta-myosin heavy chain and troponin I mutations. Pediatr. Cardiol. · 2008
- … and 77 more in the literature graph
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