Myosin-6

Function

Muscle contraction.

Classification

Family (Pfam)

PF00063 Myosin_head, PF02736 Myosin_N, PF01576 Myosin_tail_1

InterPro

Kinesin_motor_dom_sf, Myosin_head_motor_dom-like, Myosin_S1_N, Myosin_tail, P-loop_NTPase, SH3_Myosin, XRCC4-like_C

Functional cluster

Protein Serine/Threonine Kinases

Gene Ontology · 33

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005859 muscle myosin complex
• GO:0030016 myofibril
• GO:0016459 myosin complex
• GO:0032982 myosin filament
• GO:0016460 myosin II complex
• GO:0030017 sarcomere
• GO:0001725 stress fiber
• GO:0030018 Z disc
• GO:0051015 actin filament binding
• GO:0005524 ATP binding
• GO:0005516 calmodulin binding
• GO:0000146 microfilament motor activity
• GO:0017018 myosin phosphatase activity
• GO:0019901 protein kinase binding
• GO:0007512 adult heart development
• GO:0046034 ATP metabolic process
• GO:0055009 atrial cardiac muscle tissue morphogenesis
• GO:0055013 cardiac muscle cell development
• GO:0060048 cardiac muscle contraction
• GO:0001701 in utero embryonic development
• GO:0006936 muscle contraction
• GO:0030049 muscle filament sliding
• GO:0030239 myofibril assembly
• GO:0008217 regulation of blood pressure
• GO:0008016 regulation of heart contraction
• GO:0002027 regulation of heart rate
• GO:0002026 regulation of the force of heart contraction
• GO:0045214 sarcomere organization
• GO:0006941 striated muscle contraction
• GO:0055010 ventricular cardiac muscle tissue morphogenesis
• GO:0007522 visceral muscle development

Disease associations

• hypertrophic cardiomyopathy 14 MONDO:0013197
• dilated cardiomyopathy 1EE MONDO:0013198
• atrial septal defect 3 MONDO:0013567
• sick sinus syndrome 3, susceptibility to MONDO:0013568

Drugs targeting this protein · 3

• OMECAMTIV MECARBIL activator
• MAVACAMTEN inhibitor
• DANICAMTIV activator

Related proteins · sequence + function similarity

• Myosin-6 1.00
• Myosin-6 1.00
• Myosin-6 1.00
• Myosin-7 1.00
• Myosin-7 1.00
• Myosin-7 1.00
• Myosin-7 1.00
• Myosin-7 1.00
• Myosin-7 0.99
• Myosin-7 0.99
• Myosin-7 0.99
• Myosin-4 0.99

Co-cited proteins · studied together in the literature

• Myosin-7 3 shared papers
• T-box transcription factor TBX5 1 shared papers
• Troponin I, cardiac muscle 1 shared papers
• Myosin-binding protein C, cardiac-type 1 shared papers

Literature · 11 cited papers

• A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat. Genet. · 2011
• Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation · 2005
• Mutation in myosin heavy chain 6 causes atrial septal defect. Nat. Genet. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 14. Nature · 2003
• Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly. Circulation · 2002
• Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6). Genomics · 1993
• Human cardiac myosin heavy chain genes and their linkage in the genome. Nucleic Acids Res. · 1987
• Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium. J. Clin. Invest. · 1988
• Characterization of human cardiac myosin heavy chain genes. Proc. Natl. Acad. Sci. U.S.A. · 1989
• Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences. Am. J. Med. Genet. · 1991