Small ribosomal subunit protein uS15

UniProt P0ADZ4 Organism Escherichia coli (strain K12) Gene JW3134, b3165, rpsO, secC

Also known as: JW3134, b3165, rpsO, secC

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Binds to its own mRNA, stabilizing it 5-UTR and preventing its translation.

Classification

Family (Pfam): PF00312 Ribosomal_S15
InterPro: Ribosomal_uS15, Ribosomal_uS15_bact, uS15_NS1_RNA-bd_sf
Functional cluster: Small/Large Ribosomal Subunit Proteins

Experimental structures · PDB · 523

1EG0 EM 11.50A
2VAZ EM 10.00A
2YKR EM 9.80A
3IY8 EM 14.10A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
3JBU EM 3.64A
3JBV EM 3.32A
3JCD EM 3.70A
3JCE EM 3.20A
3JCJ EM 3.70A
… and 511 more

A predicted model is available from AlphaFold.

Gene Ontology · 10

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Polyribonucleotide nucleotidyltransferase 3 shared papers
Small ribosomal subunit protein bS1 1 shared papers
Lipoprotein NlpI 1 shared papers
tRNA pseudouridine synthase B 1 shared papers
Translation initiation factor IF-2 1 shared papers
30S ribosome-binding factor 1 shared papers
Small ribosomal subunit protein uS14 1 shared papers
Small ribosomal subunit protein bS16 1 shared papers
Small ribosomal subunit protein bS18 1 shared papers
Small ribosomal subunit protein uS8 1 shared papers
Small ribosomal subunit protein bS20 1 shared papers
Small ribosomal subunit protein bS6 1 shared papers

Literature · 19 cited papers

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation. PLoS Biol. · 2013
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Study of the structural dynamics of the E. coli 70S ribosome using real-space refinement. Cell · 2003
All-atom homology model of the Escherichia coli 30S ribosomal subunit. Nat. Struct. Biol. · 2002
Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
Escherichia coli proteome analysis using the gene-protein database. Electrophoresis · 1997
… and 7 more in the literature graph

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