Dopamine beta-hydroxylase

Function

Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters.

Classification

Family (Pfam)

PF03712 Cu2_monoox_C, PF01082 Cu2_monooxygen, PF03351 DOMON

InterPro

Cu2_ascorb_mOase-like_C, Cu2_ascorb_mOase_CS-1, Cu2_ascorb_mOase_CS-2, Cu2_ascorb_mOase_N, Cu2_ascorb_mOase_N_sf, Cu2_monoox_C, DBH-like, DOH_DOMON, DOMON_domain, PHM/PNGase_F_dom_sf, Tbh/DBH

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 1

• 4ZEL X-ray 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0034466 chromaffin granule lumen
• GO:0042584 chromaffin granule membrane
• GO:0005737 cytoplasm
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0016020 membrane
• GO:0034774 secretory granule lumen
• GO:0030667 secretory granule membrane
• GO:0045202 synapse
• GO:0030658 transport vesicle membrane
• GO:0003824 catalytic activity
• GO:0005507 copper ion binding
• GO:0004500 dopamine beta-monooxygenase activity
• GO:0031418 L-ascorbic acid binding
• GO:0007268 chemical synaptic transmission
• GO:0042420 dopamine catabolic process
• GO:0042421 norepinephrine biosynthetic process
• GO:0006589 octopamine biosynthetic process
• GO:0120162 positive regulation of cold-induced thermogenesis

Disease associations

• orthostatic hypotension 1 MONDO:0009123

Drugs targeting this protein · 1

• ZAMICASTAT inhibitor

Related proteins · sequence + function similarity

• Dopamine beta-hydroxylase 0.98
• Dopamine beta-hydroxylase 0.98
• Dopamine beta-hydroxylase 0.98
• Dopamine beta-hydroxylase 0.97
• Dopamine beta-hydroxylase 0.96
• DBH-like monooxygenase protein 1 0.91
• DBH-like monooxygenase protein 1 0.90
• DBH-like monooxygenase protein 1 homolog 0.84
• DBH-like monooxygenase protein 2 0.83
• DBH-like monooxygenase protein 1 0.83
• Putative DBH-like monooxygenase protein 2 0.77
• DBH-like monooxygenase protein 2 homolog 0.76

Co-cited proteins · studied together in the literature

• Dopamine beta-hydroxylase 2 shared papers
• Apolipoprotein A-IV 1 shared papers
• Thromboxane-A synthase 1 shared papers
• Apolipoprotein C-II 1 shared papers
• Alpha-adducin 1 shared papers
• Apolipoprotein C-I 1 shared papers
• Beta-3 adrenergic receptor 1 shared papers
• E-selectin 1 shared papers
• Endothelin-1 1 shared papers
• Cytochrome P450 11B2, mitochondrial 1 shared papers
• Mineralocorticoid receptor 1 shared papers
• Cytochrome P450 11B1, mitochondrial 1 shared papers

Literature · 14 cited papers

• The crystal structure of human dopamine beta-hydroxylase at 2.9 A resolution. Sci. Adv. · 2016
• Human bacterial artificial chromosome (BAC) transgenesis fully rescues noradrenergic function in dopamine beta-hydroxylase knockout mice. PLoS ONE · 2016
• A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. Am. J. Med. Genet. · 2002
• No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH). Am. J. Med. Genet. · 1999
• Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. · 1999
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells. Biochem. J. · 1996
• Functional and high level expression of human dopamine beta-hydroxylase in transgenic mice. J. Biol. Chem. · 1994
• … and 2 more in the literature graph