Beta-3 adrenergic receptor

UniProt P13945 Organism Homo sapiens Gene ADRB3, ADRB3R, B3AR

Also known as: ADRB3, ADRB3R, B3AR

Function

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis (By similarity). Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: ADR_fam, ADRB3_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster: G Protein-Coupled Receptors

Experimental structures · PDB · 2

9IJD EM 2.76A
9IJE EM 2.34A

A predicted model is available from AlphaFold.

Gene Ontology · 25

Drugs targeting this protein · 23

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Beta-3 adrenergic receptor 3 shared papers
Beta-3 adrenergic receptor 1 shared papers
Arrestin domain-containing protein 3 1 shared papers
Arrestin domain-containing protein 4 1 shared papers
Arrestin domain-containing protein 3 1 shared papers
Apolipoprotein A-IV 1 shared papers
Dopamine beta-hydroxylase 1 shared papers
Thromboxane-A synthase 1 shared papers
Apolipoprotein C-II 1 shared papers
Alpha-adducin 1 shared papers
Apolipoprotein C-I 1 shared papers
E-selectin 1 shared papers

Literature · 13 cited papers

The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. · 2011
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. · 1999
The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. J. Biol. Chem. · 1999
Functional and molecular biological evidence for a possible beta3-adrenoceptor in the human detrusor muscle. Br. J. Pharmacol. · 1999
The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J. Clin. Invest. · 1998
Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia · 1996
Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant. Endocrinology · 1996
Molecular cloning of a human beta 3-adrenergic receptor cDNA. FEBS Lett. · 1993
The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. Eur. J. Biochem. · 1993
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N. Engl. J. Med. · 1995
Molecular characterization of the human beta 3-adrenergic receptor. Science · 1989
… and 1 more in the literature graph

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