E-selectin

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

Classification

Family (Pfam)

PF00008 EGF, PF00059 Lectin_C, PF00084 Sushi

InterPro

C-type_lectin-like, C-type_lectin-like/link_sf, C-type_lectin_CS, CTDL_fold, EGF, Selectin_CTLD, Selectin_superfamily, Sushi/SCR/CCP_sf, Sushi_SCR_CCP_dom

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 14

• 1ESL X-ray 2.00A
• 1G1T X-ray 1.50A
• 4C16 X-ray 1.93A
• 4CSY X-ray 2.41A
• 6EYI X-ray 2.04A
• 6EYJ X-ray 2.20A
• 6EYK X-ray 2.21A
• 8R5L X-ray 2.20A
• 8R5M X-ray 2.49A
• 9HGU X-ray 2.30A
• 9HGV X-ray 2.46A
• 9HGW X-ray 2.20A
• … and 2 more

A predicted model is available from AlphaFold.

Gene Ontology · 28

• GO:0005901 caveola
• GO:0005905 clathrin-coated pit
• GO:0030863 cortical cytoskeleton
• GO:0009897 external side of plasma membrane
• GO:0005615 extracellular space
• GO:0045121 membrane raft
• GO:0048471 perinuclear region of cytoplasm
• GO:0005886 plasma membrane
• GO:0046872 metal ion binding
• GO:0070492 oligosaccharide binding
• GO:0043274 phospholipase binding
• GO:0033691 sialic acid binding
• GO:0004888 transmembrane signaling receptor activity
• GO:0030029 actin filament-based process
• GO:0019722 calcium-mediated signaling
• GO:0007157 heterophilic cell-cell adhesion
• GO:0006954 inflammatory response
• GO:0007159 leukocyte cell-cell adhesion
• GO:0002523 leukocyte migration involved in inflammatory response
• GO:0050901 leukocyte tethering or rolling
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:1903238 positive regulation of leukocyte tethering or rolling
• GO:0002092 positive regulation of receptor internalization
• GO:0050727 regulation of inflammatory response
• GO:0034097 response to cytokine
• GO:0070555 response to interleukin-1
• GO:0032496 response to lipopolysaccharide
• GO:0034612 response to tumor necrosis factor

Drugs targeting this protein · 3

• BIMOSIAMOSE inhibitor
• RIVIPANSEL antagonist
• UPROLESELAN antagonist

Related proteins · sequence + function similarity

• E-selectin 0.98
• E-selectin 0.98
• E-selectin 0.97
• E-selectin 0.97
• E-selectin 0.97
• E-selectin 0.94
• P-selectin 0.94
• P-selectin 0.92
• P-selectin 0.92
• P-selectin 0.92
• E-selectin 0.91
• P-selectin 0.91

Co-cited proteins · studied together in the literature

• L-selectin 2 shared papers
• P-selectin 3 shared papers
• Intercellular adhesion molecule 1 2 shared papers
• Podocalyxin-like protein 2 1 shared papers
• P-selectin glycoprotein ligand 1 1 shared papers
• EF-hand calcium-binding domain-containing protein 14 1 shared papers
• Laminin subunit beta-4 1 shared papers
• Apolipoprotein A-IV 1 shared papers
• Dopamine beta-hydroxylase 1 shared papers
• Thromboxane-A synthase 1 shared papers
• Trans-2,3-enoyl-CoA reductase-like 1 shared papers
• Probable G protein-coupled receptor 141 1 shared papers

Literature · 20 cited papers

• Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J. Biol. Chem. · 2017
• E-selectin ligand complexes adopt an extended high-affinity conformation. J. Mol. Cell Biol. · 2016
• Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas. Proc. Natl. Acad. Sci. U.S.A. · 2015
• Implications of the E-selectin S128R mutation for drug discovery. Glycobiology · 2014
• Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J. Immunol. · 2008
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. Arterioscler. Thromb. Vasc. Biol. · 2003
• Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell · 2000
• Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort. Hum. Genet. · 2000
• Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. · 1999
• A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease. J. Biomed. Sci. · 1999
• … and 8 more in the literature graph