L-selectin

Function

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.

Classification

Family (Pfam)

PF00008 EGF, PF00059 Lectin_C, PF00084 Sushi

InterPro

C-type_lectin-like, C-type_lectin-like/link_sf, C-type_lectin_CS, Compl-Cell_Adhes-Reg, CTDL_fold, EGF, L-selectin, Selectin_CTLD, Selectin_superfamily, Sushi/SCR/CCP_sf, Sushi_SCR_CCP_dom

Functional cluster

Immunoglobulin & Immune-Response Proteins

Experimental structures · PDB · 3

• 2LGF NMR
• 3CFW X-ray 2.20A
• 5VC1 X-ray 1.94A

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0009897 external side of plasma membrane
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0030667 secretory granule membrane
• GO:0005509 calcium ion binding
• GO:0030246 carbohydrate binding
• GO:0043208 glycosphingolipid binding
• GO:0008201 heparin binding
• GO:0070492 oligosaccharide binding
• GO:0002020 protease binding
• GO:0033691 sialic acid binding
• GO:0016339 calcium-dependent cell-cell adhesion
• GO:0007155 cell adhesion
• GO:0007157 heterophilic cell-cell adhesion
• GO:0007159 leukocyte cell-cell adhesion
• GO:0050901 leukocyte tethering or rolling
• GO:0034097 response to cytokine

Drugs targeting this protein · 2

• BIMOSIAMOSE inhibitor
• RIVIPANSEL antagonist

Related proteins · sequence + function similarity

• L-selectin 1.00
• L-selectin 1.00
• L-selectin 1.00
• L-selectin 1.00
• L-selectin 0.98
• L-selectin 0.98
• P-selectin 0.88
• E-selectin 0.88
• E-selectin 0.88
• E-selectin 0.86
• P-selectin 0.86
• P-selectin 0.85

Co-cited proteins · studied together in the literature

• P-selectin glycoprotein ligand 1 2 shared papers
• E-selectin 2 shared papers
• P-selectin 2 shared papers
• Podocalyxin-like protein 2 1 shared papers

Literature · 15 cited papers

• Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9 A Resolution. ChemBioChem · 2017
• Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J. Biol. Chem. · 2017
• Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat. Biotechnol. · 2009
• Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J. Immunol. · 2008
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin. J. Biol. Chem. · 2003
• Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51. J. Biol. Chem. · 2003
• A template for generation and comparison of three-dimensional selectin models. Biochem. Biophys. Res. Commun. · 1995
• Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains. Proc. Natl. Acad. Sci. U.S.A. · 1989
• Characterization of a human homologue of the murine peripheral lymph node homing receptor. J. Cell Biol. · 1989
• … and 3 more in the literature graph