P-selectin

Function

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3).

Classification

Family (Pfam)

PF00059 Lectin_C, PF00084 Sushi

InterPro

C-type_lectin-like, C-type_lectin-like/link_sf, C-type_lectin_CS, Compl-Cell_Adhes-Reg, CTDL_fold, EGF, Selectin_CTLD, Selectin_superfamily, Sushi/SCR/CCP_sf, Sushi_SCR_CCP_dom

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 5

• 1FSB NMR
• 1G1Q X-ray 2.40A
• 1G1R X-ray 3.40A
• 1G1S X-ray 1.90A
• 1HES X-ray 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 28

• GO:0009897 external side of plasma membrane
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0031092 platelet alpha granule membrane
• GO:0031088 platelet dense granule membrane
• GO:0005509 calcium ion binding
• GO:0048306 calcium-dependent protein binding
• GO:0042806 fucose binding
• GO:0043208 glycosphingolipid binding
• GO:0008201 heparin binding
• GO:0005178 integrin binding
• GO:0001530 lipopolysaccharide binding
• GO:0070492 oligosaccharide binding
• GO:0033691 sialic acid binding
• GO:0038023 signaling receptor activity
• GO:0016339 calcium-dependent cell-cell adhesion
• GO:0007155 cell adhesion
• GO:0098609 cell-cell adhesion
• GO:0050829 defense response to Gram-negative bacterium
• GO:0007157 heterophilic cell-cell adhesion
• GO:0007159 leukocyte cell-cell adhesion
• GO:0050901 leukocyte tethering or rolling
• GO:1903238 positive regulation of leukocyte tethering or rolling
• GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• GO:0010572 positive regulation of platelet activation
• GO:0033623 regulation of integrin activation
• GO:0034097 response to cytokine
• GO:0032496 response to lipopolysaccharide

Drugs targeting this protein · 2

• BIMOSIAMOSE inhibitor
• RIVIPANSEL antagonist

Related proteins · sequence + function similarity

• P-selectin 0.99
• P-selectin 0.98
• P-selectin 0.98
• P-selectin 0.98
• E-selectin 0.94
• E-selectin 0.94
• E-selectin 0.94
• E-selectin 0.94
• E-selectin 0.92
• E-selectin 0.92
• E-selectin 0.92
• E-selectin 0.90

Co-cited proteins · studied together in the literature

• P-selectin glycoprotein ligand 1 4 shared papers
• E-selectin 3 shared papers
• Sorting nexin-17 2 shared papers
• Interleukin-4 1 shared papers
• L-selectin 2 shared papers
• Podocalyxin-like protein 2 1 shared papers
• Protein patched homolog 1 1 shared papers
• Prolow-density lipoprotein receptor-related protein 1 1 shared papers
• Integrin alpha-4 1 shared papers
• Integrin alpha-IIb 1 shared papers
• Integrin alpha-5 1 shared papers
• Integrin alpha-V 1 shared papers

Literature · 18 cited papers

• The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand. Life. Sci Alliance · 2023
• Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J. Biol. Chem. · 2017
• Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins. J. Immunol. · 2008
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. Mol. Cell. Proteomics · 2006
• Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking. J. Mol. Biol. · 2005
• Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. Hum. Mol. Genet. · 2004
• A new member of the sorting nexin family interacts with the C-terminus of P-selectin. Biochem. Biophys. Res. Commun. · 2001
• Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell · 2000
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction. Hum. Mol. Genet. · 1998
• Structure and function of the epidermal growth factor domain of P-selectin. Biochemistry · 1996
• … and 6 more in the literature graph