Mineralocorticoid receptor
Also known as: MCR, MLR, NR3C2
Function
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Classification
- Family (Pfam)
- PF00104 Hormone_recep, PF00105 zf-C4
- InterPro
- NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Znf_hrmn_rcpt, Znf_NHR/GATA
- Functional cluster
- Homeobox & Zinc-Finger Transcription Factors
Experimental structures · PDB · 29
- 1Y9R X-ray 1.96A
- 1YA3 X-ray 2.34A
- 2A3I X-ray 1.95A
- 2AA2 X-ray 1.95A
- 2AA5 X-ray 2.20A
- 2AA6 X-ray 1.95A
- 2AA7 X-ray 2.20A
- 2AAX X-ray 1.75A
- 2AB2 X-ray 1.85A
- 2ABI X-ray 2.33A
- 2OAX X-ray 2.29A
- 3VHU X-ray 2.11A
- … and 17 more
A predicted model is available from AlphaFold.
Gene Ontology · 20
- GO:0000785 chromatin
- GO:0005829 cytosol
- GO:0005789 endoplasmic reticulum membrane
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0043235 receptor complex
- GO:0003700 DNA-binding transcription factor activity
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0034056 estrogen response element binding
- GO:0004879 nuclear receptor activity
- GO:0003707 nuclear steroid receptor activity
- GO:1990837 sequence-specific double-stranded DNA binding
- GO:0005496 steroid binding
- GO:0017025 TBP-class protein binding
- GO:0008270 zinc ion binding
- GO:0006351 DNA-templated transcription
- GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway
- GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
- GO:0006357 regulation of transcription by RNA polymerase II
- GO:0007165 signal transduction
Disease associations
- autosomal dominant pseudohypoaldosteronism type 1 MONDO:0008329
- pseudohyperaldosteronism type 2 MONDO:0011517
Drugs targeting this protein · 16
- EPLERENONE antagonist
- DESOXYCORTICOSTERONE ACETATE agonist
- DESOXYCORTICOSTERONE PIVALATE agonist
- FLUDROCORTISONE ACETATE agonist
- PF-03882845 antagonist
- CANRENOATE POTASSIUM antagonist
- SPIRONOLACTONE antagonist
- NIMODIPINE antagonist
- CANRENONE antagonist
- FELODIPINE antagonist
- DROSPIRENONE antagonist
- FINERENONE antagonist
- MT-3995 antagonist
- VAMOROLONE antagonist
- BALCINRENONE modulator
- LY2623091 antagonist
Related proteins · sequence + function similarity
- Mineralocorticoid receptor 1.00
- Mineralocorticoid receptor 1.00
- Mineralocorticoid receptor 1.00
- Mineralocorticoid receptor 0.99
- Mineralocorticoid receptor 0.98
- Mineralocorticoid receptor 0.98
- Glucocorticoid receptor 0.87
- Glucocorticoid receptor 0.86
- Glucocorticoid receptor 0.85
- Glucocorticoid receptor 0.85
- Glucocorticoid receptor 0.85
- Glucocorticoid receptor 0.85
Co-cited proteins · studied together in the literature
- Mineralocorticoid receptor 1 shared papers
- Transcription intermediary factor 1-alpha 1 shared papers
- 11-beta-hydroxysteroid dehydrogenase type 2 1 shared papers
- Peptidyl-prolyl cis-trans isomerase FKBP4 1 shared papers
- Nuclear receptor-interacting protein 1 1 shared papers
- Mineralocorticoid receptor 1 shared papers
- Epithelial sodium channel subunit alpha 1 shared papers
- Epithelial sodium channel subunit beta 1 shared papers
- Rho GDP-dissociation inhibitor 1 1 shared papers
- Apolipoprotein A-IV 1 shared papers
- Ras-related C3 botulinum toxin substrate 1 1 shared papers
- Serine/threonine-protein kinase PAK 1 1 shared papers
Literature · 27 cited papers
- Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PLoS ONE · 2014
- Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat. Med. · 2008
- Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism. Hum. Mutat. · 2007
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1. J. Clin. Endocrinol. Metab. · 2006
- Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor. Mol. Cell · 2005
- A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor. J. Biol. Chem. · 2005
- Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension. Nat. Struct. Mol. Biol. · 2005
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Different inactivating mutations of the mineralocorticoid receptor in fourteen families affected by type I pseudohypoaldosteronism. J. Clin. Endocrinol. Metab. · 2003
- Functional polymorphisms in the mineralocorticoid receptor and amirolide-sensitive sodium channel genes in a patient with sporadic pseudohypoaldosteronism. Hum. Genet. · 2003
- … and 15 more in the literature graph
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