Small ribosomal subunit protein uS2

UniProt P08865 Organism Homo sapiens Gene LAMBR, LAMR1, RPSA

Also known as: LAMBR, LAMR1, RPSA

Function

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.

Classification

Family (Pfam): PF16122 40S_SA_C, PF00318 Ribosomal_S2
InterPro: Ribosomal_uS2, Ribosomal_uS2_C, Ribosomal_uS2_CS, Ribosomal_uS2_euk, Ribosomal_uS2_euk_arc, Ribosomal_uS2_flav_dom_sf, Ribosomal_uS2_vert
Functional cluster: Archaeal Ribosomal & Replication Proteins

Experimental structures · PDB · 174

3BCH X-ray 2.15A
4UG0 EM
4V5Z EM 8.70A
4V6X EM 5.00A
5A2Q EM 3.90A
5AJ0 EM 3.50A
5FLX EM 3.90A
5LKS EM 3.60A
5OA3 EM 4.30A
5T2C EM 3.60A
5VYC X-ray 6.00A
6FEC EM 6.30A
… and 162 more

A predicted model is available from AlphaFold.

Gene Ontology · 20

Disease associations

familial isolated congenital asplenia MONDO:0010066

Drugs targeting this protein · 2

CYCLOHEXIMIDE inhibitor
ATALUREN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Small ribosomal subunit protein uS2 1 shared papers
Small ribosomal subunit protein uS2 1 shared papers
Small ribosomal subunit protein uS2B 1 shared papers
Small ribosomal subunit protein uS2A 1 shared papers
Protein phosphatase 1 regulatory inhibitor subunit 16B 1 shared papers
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 shared papers
Large ribosomal subunit protein eL38 1 shared papers
Large ribosomal subunit protein uL6 1 shared papers
Small ribosomal subunit protein uS7 2 shared papers
Small ribosomal subunit protein uS17 2 shared papers
Small ribosomal subunit protein uS8 2 shared papers
Small ribosomal subunit protein eS12 2 shared papers

Literature · 37 cited papers

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
Crystal structure of the human laminin receptor precursor. J. Biol. Chem. · 2008
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. J. Virol. · 2006
… and 25 more in the literature graph

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