lmmol · Proteins

Receptor tyrosine-protein kinase erbB-2

UniProt P04626 Organism Homo sapiens Gene ERBB2, HER2, MLN19, NEU, NGL EC 2.7.10.1

Also known as: ERBB2, HER2, MLN19, NEU, NGL

Function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

Classification

Family (Pfam)
PF00757 Furin-like, PF14843 GF_recep_IV, PF07714 PK_Tyr_Ser-Thr, PF01030 Recep_L_domain, PF21314 TM_ErbB1
InterPro
Furin-like_Cys-rich_dom, Furin_repeat, GF_recep_IV, Growth_fac_rcpt_cys_sf, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Rcpt_L-dom, Rcpt_L-dom_sf, RTK, Ser-Thr/Tyr_kinase_cat_dom, TM_ErbB1, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_EGF/ERB/XmrK_rcpt
Functional cluster
Secreted Growth Factors & Cytokines

Experimental structures · PDB · 59

A predicted model is available from AlphaFold.

Gene Ontology · 65

Disease associations

Drugs targeting this protein · 27

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 50 cited papers

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