lmmol · Proteins

Epidermal growth factor receptor

UniProt P00533 Organism Homo sapiens Gene EGFR, ERBB, ERBB1, HER1 EC 2.7.10.1

Also known as: EGFR, ERBB, ERBB1, HER1

Function

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity).

Classification

Family (Pfam)
PF00757 Furin-like, PF14843 GF_recep_IV, PF07714 PK_Tyr_Ser-Thr, PF01030 Recep_L_domain, PF21314 TM_ErbB1
InterPro
Furin-like_Cys-rich_dom, Furin_repeat, GF_recep_IV, Growth_fac_rcpt_cys_sf, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Rcpt_L-dom, Rcpt_L-dom_sf, RTK, Ser-Thr/Tyr_kinase_cat_dom, TM_ErbB1, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_EGF/ERB/XmrK_rcpt
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 354

A predicted model is available from AlphaFold.

Gene Ontology · 83

Disease associations

Drugs targeting this protein · 56

Neighborhood · nearest proteins

EGFREGFREgfrtuEGFLIG1EPGN
Nearest neighbours of Epidermal growth factor receptor: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 114 cited papers

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