A-type voltage-gated potassium channel KCND1

UniProt Q9NSA2 Organism Homo sapiens Gene KCND1

Also known as: KCND1

Function

A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain. Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (By similarity). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating.

Classification

Family (Pfam): PF02214 BTB_2, PF11879 DUF3399, PF00520 Ion_trans, PF11601 Shal-type
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv4, K_chnl_volt-dep_Kv4.1, K_chnl_volt-dep_Kv4_C, Shal-type_N, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Homeobox & Zinc-Finger Transcription Factors

Gene Ontology · 10

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

A-type voltage-gated potassium channel KCND2 2 shared papers
A-type potassium channel modulatory protein DPP6 1 shared papers
A-type voltage-gated potassium channel KCND3 1 shared papers
Inactive dipeptidyl peptidase 10 1 shared papers

Literature · 5 cited papers

The DNA sequence of the human X chromosome. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys. J. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). Genomics · 2000

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