Voltage-gated potassium channel KCNC4

UniProt Q03721 Organism Homo sapiens Gene C1orf30, KCNC4

Also known as: C1orf30, KCNC4

Function

Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics.

Classification

Family (Pfam): PF02214 BTB_2, PF00520 Ion_trans, PF11601 Shal-type
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv3, K_chnl_volt-dep_Kv3.4, Shal-type_N, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Nucleic Acid Metabolism & Repair Enzymes

Experimental structures · PDB · 3

1B4G NMR
1B4I NMR
1ZTN NMR

A predicted model is available from AlphaFold.

Gene Ontology · 16

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-gated potassium channel KCNC3 1 shared papers
Potassium voltage-gated channel subfamily A member 4 1 shared papers
Potassium voltage-gated channel subfamily A member 4 1 shared papers

Literature · 7 cited papers

The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nat. Struct. Biol. · 1999
Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action. J. Gen. Physiol. · 1998
NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature · 1997
Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. Neuron · 1994
Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel. Proc. R. Soc. B · 1992

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