Potassium voltage-gated channel subfamily A member 3
Also known as: HGK5, KCNA3
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv1, K_chnl_volt-dep_Kv1.3, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Homeobox & Zinc-Finger Transcription Factors
Experimental structures · PDB · 10
- 4BGC X-ray 1.20A
- 7EJ1 EM 3.20A
- 7EJ2 EM 3.30A
- 7SSV EM 3.39A
- 7SSX EM 2.89A
- 7SSY EM 2.89A
- 7SSZ EM 3.25A
- 7WF3 EM 3.40A
- 7WF4 EM 3.40A
- 8DFL EM 3.25A
A predicted model is available from AlphaFold.
Gene Ontology · 12
- GO:0030424 axon
- GO:0016020 membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0005251 delayed rectifier potassium channel activity
- GO:0005244 voltage-gated monoatomic ion channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily A member 3 0.98
- Potassium voltage-gated channel subfamily A member 3 0.98
- Potassium voltage-gated channel subfamily A member 4 0.91
- Potassium voltage-gated channel subfamily A member 4 0.91
- Potassium voltage-gated channel subfamily A member 4 0.90
- Potassium voltage-gated channel subfamily A member 5 0.90
- Potassium voltage-gated channel subfamily A member 4 0.90
- Potassium voltage-gated channel subfamily A member 4 0.90
- Potassium voltage-gated channel subfamily A member 5 0.90
- Potassium voltage-gated channel subfamily A member 6 0.89
- Potassium voltage-gated channel subfamily A member 5 0.89
- Potassium voltage-gated channel subfamily A member 6 0.88
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily A member 5 1 shared papers
Literature · 8 cited papers
- Characterization of endogenous Kv1.3 channel isoforms in T cells. J. Cell. Physiol. · 2023
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of human chromosome 1. Genomics · 1994
- Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. Proc. Natl. Acad. Sci. U.S.A. · 1991
- Characterization and functional expression of genomic DNA encoding the human lymphocyte type n potassium channel. DNA Cell Biol. · 1992
- Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. J. Biol. Chem. · 1992
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