Potassium voltage-gated channel subfamily A member 6
Also known as: KCNA6
Function
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv1, KCNA6, KCNA6_BTB_POZ, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Eukaryotic Transcription Factors & related
Gene Ontology · 11
- GO:0043679 axon terminus
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0034705 potassium channel complex
- GO:0008076 voltage-gated potassium channel complex
- GO:0005251 delayed rectifier potassium channel activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily A member 6 0.98
- Potassium voltage-gated channel subfamily A member 6 0.98
- Potassium voltage-gated channel subfamily A member 5 0.94
- Potassium voltage-gated channel subfamily A member 5 0.94
- Potassium voltage-gated channel subfamily A member 5 0.91
- Potassium voltage-gated channel subfamily A member 5 0.91
- Potassium voltage-gated channel subfamily A member 5 0.90
- Potassium voltage-gated channel subfamily A member 3 0.90
- Potassium voltage-gated channel subfamily A member 3 0.90
- Potassium voltage-gated channel subfamily A member 3 0.89
- Potassium voltage-gated channel subfamily A member 7 0.86
- Potassium voltage-gated channel subfamily A member 7 0.85
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily A member 6 1 shared papers
Literature · 4 cited papers
- De novo KCNA6 variants with attenuated KV 1.6 channel deactivation in patients with epilepsy. Epilepsia · 2022
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells. Biochem. Biophys. Res. Commun. · 2003
- Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. · 1990