Potassium voltage-gated channel subfamily A member 7
Also known as: KCNA7
Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv1, KCNA7_BTB_POZ, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Nucleic Acid Metabolism & Repair Enzymes
Gene Ontology · 7
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily A member 7 0.99
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.92
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.92
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.92
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.92
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.91
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.91
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.91
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.91
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.91
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.90
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.90
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily A member 7 1 shared papers
Literature · 2 cited papers
- Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur. J. Hum. Genet. · 2002
- Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene · 2001
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