A-type voltage-gated potassium channel KCND3

UniProt Q9UK17 Organism Homo sapiens Gene KCND3

Also known as: KCND3

Function

Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart. In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics.

Classification

Family (Pfam): PF02214 BTB_2, PF11879 DUF3399, PF00520 Ion_trans, PF11601 Shal-type
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv4, K_chnl_volt-dep_Kv4.3, K_chnl_volt-dep_Kv4_C, Shal-type_N, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Protein Serine/Threonine Kinases

Experimental structures · PDB · 6

1S1G X-ray 2.60A
2NZ0 X-ray 3.20A
7W3Y EM 3.00A
7W6N EM 3.40A
7W6S EM 2.80A
7W6T EM 3.85A

A predicted model is available from AlphaFold.

Gene Ontology · 25

Disease associations

spinocerebellar ataxia type 19/22 MONDO:0011819
Brugada syndrome 9 MONDO:0014621

Drugs targeting this protein · 7

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

A-type potassium channel modulatory protein KCNIP1 3 shared papers
A-type voltage-gated potassium channel KCND2 4 shared papers
Major vault protein 1 shared papers
A-type potassium channel modulatory protein KCNIP2 2 shared papers
A-type voltage-gated potassium channel KCND1 1 shared papers
A-type potassium channel modulatory protein DPP6 1 shared papers
A-type voltage-gated potassium channel KCND2 2 shared papers
A-type voltage-gated potassium channel KCND3 1 shared papers
Disks large homolog 1 1 shared papers
Disks large homolog 1 1 shared papers

Literature · 16 cited papers

Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res. · 2022
Novel de novo KCND3 mutation in a Japanese patient with intellectual disability, cerebellar ataxia, myoclonus, and dystonia. Cerebellum · 2018
Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19. Ann. Neurol. · 2012
Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann. Neurol. · 2012
Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death. Hum. Mutat. · 2012
Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome. Heart Rhythm · 2011
Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes. Circ. Res. · 2009
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits. Nat. Neurosci. · 2007
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Neuron · 2004
… and 4 more in the literature graph

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