3',5'-cyclic-AMP phosphodiesterase 7B

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.

Classification

Family (Pfam)

PF00233 PDEase_I

InterPro

HD/PDEase_dom, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Eukaryotic Transcription Factors & related

Gene Ontology · 9

• GO:0005829 cytosol
• GO:0045202 synapse
• GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0046872 metal ion binding
• GO:0006198 cAMP catabolic process
• GO:0007268 chemical synaptic transmission
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0007165 signal transduction

Drugs targeting this protein · 3

• FLAVOXATE HYDROCHLORIDE inhibitor
• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• 3',5'-cyclic-AMP phosphodiesterase 7B 0.99
• High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 0.91
• High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 0.88
• High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 0.88
• 3',5'-cyclic-AMP phosphodiesterase 4C 0.55
• cGMP-specific 3',5'-cyclic phosphodiesterase 0.55
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.55
• cGMP-specific 3',5'-cyclic phosphodiesterase 0.55
• Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 0.55
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.54
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.54
• cGMP-specific 3',5'-cyclic phosphodiesterase 0.54

Co-cited proteins · studied together in the literature

• 3',5'-cyclic-AMP phosphodiesterase 7B 1 shared papers

Literature · 5 cited papers

• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Cloning and characterisation of the human and mouse PDE7B, a novel cAMP-specific nucleotide phosphodiesterase. Biochem. Biophys. Res. Commun. · 2000
• Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem. Biophys. Res. Commun. · 2000