High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Classification

Family (Pfam)

PF00233 PDEase_I

InterPro

HD/PDEase_dom, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Zinc-Finger & Chromatin Regulatory Proteins

Experimental structures · PDB · 4

• 1ZKL X-ray 1.67A
• 3G3N X-ray 2.40A
• 4PM0 X-ray 2.10A
• 4Y2B X-ray 2.20A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005829 cytosol
• GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0046872 metal ion binding
• GO:0006198 cAMP catabolic process
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0007165 signal transduction

Drugs targeting this protein · 3

• FLAVOXATE HYDROCHLORIDE inhibitor
• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 0.97
• High affinity 3',5'-cyclic-AMP phosphodiesterase 7A 0.95
• 3',5'-cyclic-AMP phosphodiesterase 7B 0.88
• 3',5'-cyclic-AMP phosphodiesterase 7B 0.88
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.62
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.62
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.62
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.62
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.61
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.60
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.58
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.57

Co-cited proteins · studied together in the literature

• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 1 shared papers
• A-kinase anchor protein 8 1 shared papers
• Transcriptional corepressor CBFA2T3 1 shared papers

Literature · 9 cited papers

• Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. ChemMedChem · 2009
• DNA sequence and analysis of human chromosome 8. Nature · 2006
• Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines. J. Immunol. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. Proc. Natl. Acad. Sci. U.S.A. · 2001
• Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart. J. Biol. Chem. · 1997
• Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J. Biol. Chem. · 1993