Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

Function

Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Classification

Family (Pfam)

PF00233 PDEase_I, PF08499 PDEase_I_N

InterPro

HD/PDEase_dom, PDE1_N, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 7

• 1TAZ X-ray 1.77A
• 4NPV X-ray 2.40A
• 4NPW X-ray 1.90A
• 5B25 X-ray 1.90A
• 5UOY X-ray 1.82A
• 5UP0 X-ray 2.04A
• 5W6E X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005829 cytosol
• GO:0043025 neuronal cell body
• GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0005516 calmodulin binding
• GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0046872 metal ion binding
• GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
• GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
• GO:0030224 monocyte differentiation
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0007165 signal transduction

Drugs targeting this protein · 2

• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1.00
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1.00
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.99
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.99
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.96
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.96
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.95
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.85
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.85
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.84
• Probable 3',5'-cyclic phosphodiesterase pde-1 0.81
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 0.72

Co-cited proteins · studied together in the literature

• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 1 shared papers
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1 shared papers
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1 shared papers
• cGMP-specific 3',5'-cyclic phosphodiesterase 1 shared papers
• cGMP-dependent 3',5'-cyclic phosphodiesterase 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4D 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4B 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4D 1 shared papers

Literature · 7 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases. Mol. Cell · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. Cell. Signal. · 2002
• Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. Cell. Signal. · 1997
• Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc. Natl. Acad. Sci. U.S.A. · 1996
• A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. J. Biol. Chem. · 1992