Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

Function

Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP.

Classification

Family (Pfam)

PF00233 PDEase_I, PF08499 PDEase_I_N

InterPro

HD/PDEase_dom, PDE1_N, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Mixed Regulatory & Membrane Proteins

Gene Ontology · 11

• GO:0005829 cytosol
• GO:0043025 neuronal cell body
• GO:0005516 calmodulin binding
• GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0046872 metal ion binding
• GO:0046069 cGMP catabolic process
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0034391 regulation of smooth muscle cell apoptotic process
• GO:0048660 regulation of smooth muscle cell proliferation
• GO:0007165 signal transduction

Drugs targeting this protein · 2

• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.99
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0.99
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.96
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.95
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.95
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.95
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 0.95
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.89
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.89
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 0.88
• Probable 3',5'-cyclic phosphodiesterase pde-1 0.80
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 0.71

Co-cited proteins · studied together in the literature

• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C 1 shared papers
• Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B 1 shared papers
• Adenylate kinase isoenzyme 5 1 shared papers
• Adenylate kinase isoenzyme 5 1 shared papers
• LIM domain-binding protein 1 1 shared papers
• Rho guanine nucleotide exchange factor 7 1 shared papers
• MAP kinase-activating death domain protein 1 shared papers
• 14-3-3 protein zeta/delta 1 shared papers
• MAP/microtubule affinity-regulating kinase 4 1 shared papers
• MAP/microtubule affinity-regulating kinase 3 1 shared papers
• ARF GTPase-activating protein GIT1 1 shared papers
• 14-3-3 protein zeta/delta 1 shared papers

Literature · 6 cited papers

• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol. Cell. Proteomics · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. Cell. Signal. · 2002
• Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. Biochim. Biophys. Acta · 2001
• Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. J. Biol. Chem. · 1996