3',5'-cyclic-AMP phosphodiesterase 4C
Also known as: DPDE1, PDE4C
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Classification
- Family (Pfam)
- PF18100 PDE4_UCR, PF00233 PDEase_I
- InterPro
- HD/PDEase_dom, PDE4_UCR, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS
- Functional cluster
- Eukaryotic Transcription Factors & related
Experimental structures · PDB · 1
- 2QYM X-ray 1.90A
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005929 cilium
- GO:0005829 cytosol
- GO:0005615 extracellular space
- GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
- GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
- GO:0046872 metal ion binding
- GO:0006198 cAMP catabolic process
- GO:0141162 negative regulation of cAMP/PKA signal transduction
- GO:0007165 signal transduction
Drugs targeting this protein · 28
- AMLEXANOX inhibitor
- OXTRIPHYLLINE inhibitor
- THEOPHYLLINE SODIUM GLYCINATE inhibitor
- FLAVOXATE HYDROCHLORIDE inhibitor
- THEOPHYLLINE inhibitor
- AMINOPHYLLINE inhibitor
- DYPHYLLINE inhibitor
- ROFLUMILAST inhibitor
- IBUDILAST inhibitor
- TOFIMILAST inhibitor
- TRANIMILAST inhibitor
- TETOMILAST inhibitor
- LOTAMILAST inhibitor
- DIFAMILAST inhibitor
- HT-0712 inhibitor
- DOVRAMILAST inhibitor
- OGLEMILAST inhibitor
- REVAMILAST inhibitor
- ENSIFENTRINE inhibitor
- CRISABOROLE inhibitor
- MK-0873 inhibitor
- CILOMILAST inhibitor
- APREMILAST inhibitor
- DROTAVERINE inhibitor
- GSK-256066 inhibitor
- PENTOXIFYLLINE inhibitor
- ROLIPRAM inhibitor
- DIPYRIDAMOLE inhibitor
Related proteins · sequence + function similarity
- 3',5'-cyclic-AMP phosphodiesterase 4A 0.94
- 3',5'-cyclic-AMP phosphodiesterase 4A 0.93
- 3',5'-cyclic-AMP phosphodiesterase 4C 0.92
- 3',5'-cyclic-AMP phosphodiesterase 4A 0.89
- 3',5'-cyclic-AMP phosphodiesterase 4C 0.88
- 3',5'-cyclic-AMP phosphodiesterase 4D 0.86
- 3',5'-cyclic-AMP phosphodiesterase 4D 0.85
- 3',5'-cyclic-AMP phosphodiesterase 4D 0.85
- 3',5'-cyclic-AMP phosphodiesterase 4B 0.85
- 3',5'-cyclic-AMP phosphodiesterase 4B 0.83
- 3',5'-cyclic-AMP phosphodiesterase, isoform F 0.69
- Kinesin-like protein KIF18B 0.66
Co-cited proteins · studied together in the literature
- Ras-related protein Rab-3A 1 shared papers
- 3',5'-cyclic-AMP phosphodiesterase 4A 2 shared papers
- 3',5'-cyclic-AMP phosphodiesterase 4B 2 shared papers
- 3',5'-cyclic-AMP phosphodiesterase 4D 2 shared papers
Literature · 6 cited papers
- Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem. J. · 2007
- The DNA sequence and biology of human chromosome 19. Nature · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. Cell. Signal. · 1999
- A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol. Cell. Biol. · 1993
- Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). FEBS Lett. · 1995
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