3',5'-cyclic-AMP phosphodiesterase 4A

Function

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.

Classification

Family (Pfam)

PF18100 PDE4_UCR, PF00233 PDEase_I

InterPro

HD/PDEase_dom, PDE4_UCR, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 3

• 2QYK X-ray 2.10A
• 3I8V X-ray 2.25A
• 3TVX X-ray 2.84A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005829 cytosol
• GO:0019898 extrinsic component of membrane
• GO:0016020 membrane
• GO:0048471 perinuclear region of cytoplasm
• GO:0005886 plasma membrane
• GO:0032587 ruffle membrane
• GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0030552 cAMP binding
• GO:0046872 metal ion binding
• GO:0006198 cAMP catabolic process
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0007165 signal transduction

Drugs targeting this protein · 28

• AMLEXANOX inhibitor
• OXTRIPHYLLINE inhibitor
• THEOPHYLLINE SODIUM GLYCINATE inhibitor
• FLAVOXATE HYDROCHLORIDE inhibitor
• THEOPHYLLINE inhibitor
• AMINOPHYLLINE inhibitor
• DYPHYLLINE inhibitor
• ROFLUMILAST inhibitor
• IBUDILAST inhibitor
• TOFIMILAST inhibitor
• TRANIMILAST inhibitor
• TETOMILAST inhibitor
• LOTAMILAST inhibitor
• DIFAMILAST inhibitor
• HT-0712 inhibitor
• DOVRAMILAST inhibitor
• OGLEMILAST inhibitor
• REVAMILAST inhibitor
• ENSIFENTRINE inhibitor
• CRISABOROLE inhibitor
• MK-0873 inhibitor
• CILOMILAST inhibitor
• APREMILAST inhibitor
• DROTAVERINE inhibitor
• GSK-256066 inhibitor
• PENTOXIFYLLINE inhibitor
• ROLIPRAM inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• 3',5'-cyclic-AMP phosphodiesterase 4A 0.96
• 3',5'-cyclic-AMP phosphodiesterase 4A 0.93
• 3',5'-cyclic-AMP phosphodiesterase 4D 0.89
• 3',5'-cyclic-AMP phosphodiesterase 4C 0.89
• 3',5'-cyclic-AMP phosphodiesterase 4D 0.89
• 3',5'-cyclic-AMP phosphodiesterase 4C 0.87
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.83
• 3',5'-cyclic-AMP phosphodiesterase 4D 0.83
• 3',5'-cyclic-AMP phosphodiesterase 4C 0.81
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.81
• 3',5'-cyclic-AMP phosphodiesterase, isoform F 0.73
• Mitogen-activated protein kinase kinase kinase 12 0.66

Co-cited proteins · studied together in the literature

• 3',5'-cyclic-AMP phosphodiesterase 4A 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4A 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4D 3 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4C 2 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4A 1 shared papers
• 3',5'-cyclic-AMP phosphodiesterase 4B 2 shared papers
• Beta-arrestin-2 1 shared papers
• Tyrosine-protein kinase Lyn 1 shared papers

Literature · 17 cited papers

• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem. J. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochem. J. · 2008
• Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem. J. · 2007
• Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Mol. Pharmacol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and biology of human chromosome 19. Nature · 2004
• An unappreciated role for RNA surveillance. Genome Biol. · 2004
• Purification and characterization of the human pde4a catalytic domain (pde4a(330-723)) expressed in sf9 cells. Arch. Biochem. Biophys. · 2001
• Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10. Mol. Pharmacol. · 2001
• … and 5 more in the literature graph