Estrogen receptor beta

UniProt Q92731 Organism Homo sapiens Gene ESR2, ESTRB, NR3A2

Also known as: ESR2, ESTRB, NR3A2

Function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.

Classification

Family (Pfam): PF12497 ERbeta_N, PF00104 Hormone_recep, PF00105 zf-C4
InterPro: ER-beta-like_N, ER-beta/gamma, Est_rcpt/est-rel_rcp, NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Nuclear_hrmn_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA
Functional cluster: Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 39

1L2J X-ray 2.95A
1NDE X-ray 3.00A
1QKM X-ray 1.80A
1U3Q X-ray 2.40A
1U3R X-ray 2.21A
1U3S X-ray 2.50A
1U9E X-ray 2.40A
1X76 X-ray 2.20A
1X78 X-ray 2.30A
1X7B X-ray 2.30A
1X7J X-ray 2.30A
1YY4 X-ray 2.70A
… and 27 more

A predicted model is available from AlphaFold.

Gene Ontology · 26

Disease associations

ovarian dysgenesis 8 MONDO:0032590

Drugs targeting this protein · 25

RALOXIFENE HYDROCHLORIDE modulator
DIETHYLSTILBESTROL DIPHOSPHATE agonist
TOREMIFENE CITRATE modulator
ESTRAMUSTINE PHOSPHATE SODIUM modulator
CHLOROTRIANISENE modulator
QUINESTROL agonist
CYCLOFENIL modulator
ESTRIOL modulator
AUS-131 agonist
OSPEMIFENE modulator
BAZEDOXIFENE ACETATE modulator
FISPEMIFENE modulator
ARZOXIFENE modulator
ERTEBEREL agonist
ALLYLESTRENOL agonist
LASOFOXIFENE modulator
MK-6913 agonist
CHF4227 modulator
PRINABEREL agonist
DROLOXIFENE modulator
AFIMOXIFENE modulator
LASOFOXIFENE TARTRATE modulator
ESTETROL agonist
IDOXIFENE modulator
ACOLBIFENE modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Coiled-coil domain-containing protein 62 1 shared papers
Estrogen receptor beta 1 shared papers
A-kinase anchor protein 13 1 shared papers
Thioredoxin reductase 1, cytoplasmic 1 shared papers
Estrogen receptor 7 shared papers
Nuclear receptor coactivator 5 1 shared papers
Deoxynucleotidyltransferase terminal-interacting protein 2 1 shared papers
Nuclear receptor coactivator 5 1 shared papers
Peroxisome proliferator-activated receptor gamma 3 shared papers
Nuclear receptor coactivator 6 1 shared papers
Cell cycle and apoptosis regulator protein 2 1 shared papers
Proline-, glutamic acid- and leucine-rich protein 1 2 shared papers

Literature · 26 cited papers

Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor beta (ESR2). J. Clin. Endocrinol. Metab. · 2018
Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development. Genet. Med. · 2018
Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem. Biophys. Res. Commun. · 2010
PMID 19666546 Proc. Natl. Acad. Sci. U.S.A. · 2009
CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. Carcinogenesis · 2009
Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling. Proc. Natl. Acad. Sci. U.S.A. · 2006
Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway. J. Steroid Biochem. Mol. Biol. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. J. Biol. Chem. · 2004
ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. Biochem. Biophys. Res. Commun. · 2004
An unappreciated role for RNA surveillance. Genome Biol. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
… and 14 more in the literature graph

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