lmmol · Proteins

Estrogen receptor

UniProt P03372 Organism Homo sapiens Gene ESR, ESR1, NR3A1

Also known as: ESR, ESR1, NR3A1

Function

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity).

Classification

Family (Pfam)
PF12743 ESR1_C, PF00104 Hormone_recep, PF02159 Oest_recep, PF00105 zf-C4
InterPro
Est_rcpt/est-rel_rcp, Estr_rcpt, Estr_rcpt_N, NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Nuclear_hrmn_rcpt, Oestrogen-typ_rcpt_final_C_dom, Znf_hrmn_rcpt, Znf_NHR/GATA
Functional cluster
Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 473

A predicted model is available from AlphaFold.

Gene Ontology · 60

Disease associations

Drugs targeting this protein · 42

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 111 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.