lmmol · Proteins

Peroxisome proliferator-activated receptor gamma

UniProt P37231 Organism Homo sapiens Gene NR1C3, PPARG

Also known as: NR1C3, PPARG

Function

Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids. Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites. Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression. Specifically binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase (By similarity). Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity).

Classification

Family (Pfam)
PF00104 Hormone_recep, PF12577 PPARgamma_N, PF00105 zf-C4
InterPro
1Cnucl_rcpt, NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR1, Nuclear_hrmn_rcpt, PPAR-gamma, PPARgamma_N, Znf_hrmn_rcpt, Znf_NHR/GATA
Functional cluster
Protein Serine/Threonine Kinases

Experimental structures · PDB · 321

A predicted model is available from AlphaFold.

Gene Ontology · 104

Disease associations

Drugs targeting this protein · 33

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 53 cited papers

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