Tubulin alpha-1A chain
Also known as: TUBA1A, TUBA3
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Classification
- Family (Pfam)
- PF00091 Tubulin, PF03953 Tubulin_C
- InterPro
- Alpha_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
- Functional cluster
- Tubulins & Mitochondrial Metabolic Enzymes
Experimental structures · PDB · 8
- 5JCO EM 4.00A
- 6J8F X-ray 2.28A
- 6WSL EM 3.10A
- 7C1M NMR
- 7UN1 EM 6.00A
- 7UNG EM 3.60A
- 8J07 EM 4.10A
- 8SH7 EM 2.80A
A predicted model is available from AlphaFold.
Gene Ontology · 60
- GO:0005879 axonemal microtubule
- GO:0005929 cilium
- GO:0000793 condensed chromosome
- GO:0005737 cytoplasm
- GO:0036464 cytoplasmic ribonucleoprotein granule
- GO:0005829 cytosol
- GO:0070062 extracellular exosome
- GO:0005874 microtubule
- GO:0015630 microtubule cytoskeleton
- GO:0031594 neuromuscular junction
- GO:0005634 nucleus
- GO:0005886 plasma membrane
- GO:0055037 recycling endosome
- GO:0036126 sperm flagellum
- GO:0005525 GTP binding
- GO:0016787 hydrolase activity
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0008017 microtubule binding
- GO:0046982 protein heterodimerization activity
- GO:0044877 protein-containing complex binding
- GO:0051087 protein-folding chaperone binding
- GO:0005200 structural constituent of cytoskeleton
- GO:0005198 structural molecule activity
- GO:0006458 'de novo' protein folding
- GO:0008344 adult locomotory behavior
- GO:0051301 cell division
- GO:0071277 cellular response to calcium ion
- GO:0007098 centrosome cycle
- GO:0021696 cerebellar cortex morphogenesis
- GO:0021987 cerebral cortex development
- GO:0030705 cytoskeleton-dependent intracellular transport
- GO:0021542 dentate gyrus development
- GO:0030317 flagellated sperm motility
- GO:0048853 forebrain morphogenesis
- GO:0010001 glial cell differentiation
- GO:0048873 homeostasis of number of cells within a tissue
- GO:0006886 intracellular protein transport
- GO:0035641 locomotory exploration behavior
- GO:0007613 memory
- GO:0000226 microtubule cytoskeleton organization
- GO:0046785 microtubule polymerization
- GO:0007017 microtubule-based process
- GO:0000278 mitotic cell cycle
- GO:0061744 motor behavior
- GO:0051402 neuron apoptotic process
- GO:0030182 neuron differentiation
- GO:0001764 neuron migration
- GO:0140058 neuron projection arborization
- GO:0072384 organelle transport along microtubule
- GO:0050821 protein stabilization
- GO:0021859 pyramidal neuron differentiation
- GO:0050807 regulation of synapse organization
- GO:1902065 response to L-glutamate
- GO:0009612 response to mechanical stimulus
- GO:0034612 response to tumor necrosis factor
- GO:0007224 smoothened signaling pathway
- GO:0001964 startle response
- GO:0050808 synapse organization
- GO:0008542 visual learning
Disease associations
- lissencephaly due to TUBA1A mutation MONDO:0012703
Drugs targeting this protein · 35
- COLCHICINE inhibitor
- ANG1005 inhibitor
- PLINABULIN inhibitor
- CABAZITAXEL inhibitor
- IXABEPILONE inhibitor
- ERIBULIN MESYLATE inhibitor
- DAVUNETIDE stabiliser
- CROLIBULIN inhibitor
- VINFLUNINE DITARTRATE inhibitor
- FOSBRETABULIN TROMETHAMINE disrupting agent
- MILATAXEL inhibitor
- VINFLUNINE inhibitor
- TASIDOTIN inhibitor
- SAGOPILONE stabiliser
- FOSBRETABULIN DISODIUM inhibitor
- DOCETAXEL inhibitor
- VINBLASTINE SULFATE inhibitor
- DOLASTATIN-10 inhibitor
- SOBLIDOTIN inhibitor
- LAROTAXEL stabiliser
- PACLITAXEL inhibitor
- BMS-275183 stabiliser
- KOS-1584 stabiliser
- T-900607 disrupting agent
- PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
- PLOCABULIN inhibitor
- VERUBULIN disrupting agent
- INDIBULIN inhibitor
- VINCRISTINE SULFATE inhibitor
- VINORELBINE TARTRATE inhibitor
- LEXIBULIN inhibitor
- OMBRABULIN inhibitor
- DOCETAXEL ANHYDROUS stabiliser
- PATUPILONE stabiliser
- EPOTHILONE D stabiliser
Related proteins · sequence + function similarity
- Tubulin alpha-1A chain 1.00
- Tubulin alpha-1A chain 1.00
- Tubulin alpha-1A chain 1.00
- Tubulin alpha-1A chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
- Tubulin alpha-1B chain 1.00
Co-cited proteins · studied together in the literature
- Tubulin alpha-1B chain 10 shared papers
- Tubulin beta chain 1 shared papers
- Histone-lysine N-methyltransferase SETD2 1 shared papers
- Tubulin alpha-3C chain 6 shared papers
- Tubulin alpha-3D chain 6 shared papers
- Tubulin alpha-3E chain 6 shared papers
- Tubulin alpha-1C chain 6 shared papers
- Tubulin beta chain 3 shared papers
- Protein bicaudal D homolog 2 1 shared papers
- Tubulin--tyrosine ligase 1 shared papers
- Tubulin alpha-4A chain 3 shared papers
- Tubulin polyglutamylase ttll-4 1 shared papers
Literature · 20 cited papers
- SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Proc. Natl. Acad. Sci. U.S.A. · 2022
- Posttranslational modification of microtubules by the MATCAP detyrosinase. Science · 2022
- Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Nat. Struct. Mol. Biol. · 2020
- Vasohibins encode tubulin detyrosinating activity. Science · 2017
- Dual chromatin and cytoskeletal remodeling by SETD2. Cell · 2016
- Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. Cell Rep. · 2016
- Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility. EMBO J. · 2016
- Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
- Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Science · 2015
- Diagnostic yield of genetic testing in epileptic encephalopathy in childhood. Epilepsia · 2015
- Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell · 2014
- Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
- … and 8 more in the literature graph
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