Tubulin alpha-3E chain

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam)

PF00091 Tubulin, PF03953 Tubulin_C

InterPro

Alpha_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase

Functional cluster

Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 10

• GO:0005737 cytoplasm
• GO:0005874 microtubule
• GO:0015630 microtubule cytoskeleton
• GO:0005634 nucleus
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding
• GO:0005200 structural constituent of cytoskeleton
• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle

Drugs targeting this protein · 35

• COLCHICINE inhibitor
• ANG1005 inhibitor
• PLINABULIN inhibitor
• CABAZITAXEL inhibitor
• IXABEPILONE inhibitor
• ERIBULIN MESYLATE inhibitor
• DAVUNETIDE stabiliser
• CROLIBULIN inhibitor
• VINFLUNINE DITARTRATE inhibitor
• FOSBRETABULIN TROMETHAMINE disrupting agent
• MILATAXEL inhibitor
• VINFLUNINE inhibitor
• TASIDOTIN inhibitor
• SAGOPILONE stabiliser
• FOSBRETABULIN DISODIUM inhibitor
• DOCETAXEL inhibitor
• VINBLASTINE SULFATE inhibitor
• DOLASTATIN-10 inhibitor
• SOBLIDOTIN inhibitor
• LAROTAXEL stabiliser
• PACLITAXEL inhibitor
• BMS-275183 stabiliser
• KOS-1584 stabiliser
• T-900607 disrupting agent
• PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
• PLOCABULIN inhibitor
• VERUBULIN disrupting agent
• INDIBULIN inhibitor
• VINCRISTINE SULFATE inhibitor
• VINORELBINE TARTRATE inhibitor
• LEXIBULIN inhibitor
• OMBRABULIN inhibitor
• DOCETAXEL ANHYDROUS stabiliser
• PATUPILONE stabiliser
• EPOTHILONE D stabiliser

Related proteins · sequence + function similarity

• Tubulin alpha-3 chain 1.00
• Tubulin alpha-3D chain 1.00
• Tubulin alpha-3 chain 1.00
• Tubulin alpha-3C chain 1.00
• Tubulin alpha-3 chain 1.00
• Tubulin alpha chain, testis-specific 0.99
• Tubulin alpha-1 chain 0.99
• Tubulin alpha-1 chain 0.99
• Tubulin alpha-3 chain 0.99
• Tubulin alpha chain 0.99
• Tubulin alpha-1C chain 0.99
• Tubulin alpha-1C chain 0.99

Co-cited proteins · studied together in the literature

• Tubulin alpha-3C chain 6 shared papers
• Tubulin alpha-3D chain 6 shared papers
• Tubulin alpha-1C chain 6 shared papers
• Tubulin alpha-1A chain 6 shared papers
• Tubulin alpha-1B chain 6 shared papers
• Tubulin--tyrosine ligase 1 shared papers
• Tubulin alpha-4A chain 3 shared papers
• Microtubule-associated tyrosine carboxypeptidase 1 1 shared papers
• Microtubule-associated tyrosine carboxypeptidase 1 1 shared papers
• CAP-Gly domain-containing linker protein 1 1 shared papers
• Tubulin alpha-8 chain 2 shared papers
• Alpha-tubulin N-acetyltransferase 1 1 shared papers

Literature · 9 cited papers

• Posttranslational modification of microtubules by the MATCAP detyrosinase. Science · 2022
• Vasohibins encode tubulin detyrosinating activity. Science · 2017
• Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. Cell Rep. · 2016
• Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
• Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Science · 2015
• Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell · 2014
• Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. Cell · 2009
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004