Tubulin alpha-1C chain

UniProt Q9BQE3 Organism Homo sapiens Gene TUBA1C, TUBA6 EC 3.6.5.-

Also known as: TUBA1C, TUBA6

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Classification

Family (Pfam): PF00091 Tubulin, PF03953 Tubulin_C
InterPro: Alpha_tubulin, Tub_FtsZ_C, Tubulin, Tubulin/FtsZ-like_C, Tubulin/FtsZ_2-layer-sand-dom, Tubulin/FtsZ_GTPase_sf, Tubulin_C, Tubulin_CS, Tubulin_FtsZ_GTPase
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Gene Ontology · 18

Disease associations

oocyte/zygote/embryo maturation arrest 24 MONDO:0979232

Drugs targeting this protein · 35

COLCHICINE inhibitor
ANG1005 inhibitor
PLINABULIN inhibitor
CABAZITAXEL inhibitor
IXABEPILONE inhibitor
ERIBULIN MESYLATE inhibitor
DAVUNETIDE stabiliser
CROLIBULIN inhibitor
VINFLUNINE DITARTRATE inhibitor
FOSBRETABULIN TROMETHAMINE disrupting agent
MILATAXEL inhibitor
VINFLUNINE inhibitor
TASIDOTIN inhibitor
SAGOPILONE stabiliser
FOSBRETABULIN DISODIUM inhibitor
DOCETAXEL inhibitor
VINBLASTINE SULFATE inhibitor
DOLASTATIN-10 inhibitor
SOBLIDOTIN inhibitor
LAROTAXEL stabiliser
PACLITAXEL inhibitor
BMS-275183 stabiliser
KOS-1584 stabiliser
T-900607 disrupting agent
PACLITAXEL DOCOSAHEXAENOIC ACID stabiliser
PLOCABULIN inhibitor
VERUBULIN disrupting agent
INDIBULIN inhibitor
VINCRISTINE SULFATE inhibitor
VINORELBINE TARTRATE inhibitor
LEXIBULIN inhibitor
OMBRABULIN inhibitor
DOCETAXEL ANHYDROUS stabiliser
PATUPILONE stabiliser
EPOTHILONE D stabiliser

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Tubulin alpha-4A chain 4 shared papers
Tubulin alpha-3C chain 6 shared papers
Tubulin alpha-3D chain 6 shared papers
Tubulin alpha-3E chain 6 shared papers
Tubulin alpha-1A chain 6 shared papers
Tubulin alpha-1B chain 6 shared papers
Tubulin--tyrosine ligase 1 shared papers
Microtubule-associated tyrosine carboxypeptidase 1 1 shared papers
Microtubule-associated tyrosine carboxypeptidase 1 1 shared papers
CAP-Gly domain-containing linker protein 1 1 shared papers
Tubulin alpha-8 chain 2 shared papers
Alpha-tubulin N-acetyltransferase 1 1 shared papers

Literature · 18 cited papers

Biallelic variants in alpha-tubulin isotypes cause female infertility characterised as recurrent preimplantation embryo arrest. J. Med. Genet. · 2024
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science · 2022
Vasohibins encode tubulin detyrosinating activity. Science · 2017
Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. Cell Rep. · 2016
Graded control of microtubule severing by tubulin glutamylation. Cell · 2016
Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Science · 2015
Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
… and 6 more in the literature graph

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