Envelope glycoprotein D

Function

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).

Classification

Family (Pfam)

PF01537 Herpes_glycop_D

InterPro

Herpes_glycop_dom, Ig-like_dom_sf

Functional cluster

Viral Envelope Glycoproteins

Experimental structures · PDB · 1

• 3U82 X-ray 3.16A

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0044177 host cell Golgi apparatus
• GO:0016020 membrane
• GO:0019031 viral envelope
• GO:0055036 virion membrane
• GO:0046872 metal ion binding
• GO:0048018 receptor ligand activity
• GO:0098670 entry receptor-mediated virion attachment to host cell
• GO:0046718 symbiont entry into host cell

Drugs targeting this protein · 1

• DOCOSANOL inhibitor

Related proteins · sequence + function similarity

• Envelope glycoprotein D 1.00
• Envelope glycoprotein D 1.00
• Envelope glycoprotein D 1.00
• Envelope glycoprotein D 0.99
• Envelope glycoprotein D 0.98
• Envelope glycoprotein D 0.93
• Envelope glycoprotein D 0.93
• Envelope glycoprotein D 0.78
• Envelope glycoprotein D 0.72
• Protein UL141 0.71
• Envelope glycoprotein G 0.69
• Envelope glycoprotein G 0.69

Co-cited proteins · studied together in the literature

• Envelope glycoprotein D 1 shared papers
• Nectin-1 1 shared papers
• S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 1 shared papers
• Envelope glycoprotein B 1 shared papers
• Envelope glycoprotein H 1 shared papers
• Envelope glycoprotein E 2 shared papers
• Tegument protein VP16 1 shared papers
• Tegument protein VP22 1 shared papers
• Envelope glycoprotein G 2 shared papers
• Protein US2 1 shared papers
• Protein US8.5 1 shared papers
• ICP47 protein 2 shared papers

Literature · 8 cited papers

• The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin. Front. Immunol. · 2019
• Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nat. Commun. · 2011
• Virion incorporation of the herpes simplex virus type 1 tegument protein VP22 occurs via glycoprotein E-specific recruitment to the late secretory pathway. J. Virol. · 2009
• Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein. J. Virol. · 2007
• Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
• Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. · 1985
• The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
• Disulfide bond structure of glycoprotein D of herpes simplex virus types 1 and 2. J. Virol. · 1992