Envelope glycoprotein H

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.

Classification

Family (Pfam)

PF17488 Herpes_glycoH_C, PF02489 Herpes_glycop_H

InterPro

Herpes_gH, Herpes_glycoH_C, Herpes_glycoH_C_sf

Functional cluster

Nucleic Acid Metabolism & Repair Enzymes

Experimental structures · PDB · 1

• 2LQY NMR

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0044175 host cell endosome membrane
• GO:0020002 host cell plasma membrane
• GO:0019031 viral envelope
• GO:0055036 virion membrane
• GO:0019064 fusion of virus membrane with host plasma membrane
• GO:0046718 symbiont entry into host cell

Drugs targeting this protein · 1

• DOCOSANOL inhibitor

Related proteins · sequence + function similarity

• Envelope glycoprotein H 1.00
• Envelope glycoprotein H 1.00
• Envelope glycoprotein H 0.95
• Envelope glycoprotein H 0.80
• Envelope glycoprotein H 0.79
• Envelope glycoprotein H 0.79
• Capsid vertex component 1 0.79
• Major capsid protein 0.77
• Envelope glycoprotein H 0.76
• Envelope glycoprotein D 0.73
• Envelope glycoprotein H 0.72
• Envelope glycoprotein H 0.72

Co-cited proteins · studied together in the literature

• Envelope glycoprotein L 2 shared papers
• Envelope glycoprotein L 1 shared papers
• Tegument protein VP16 1 shared papers
• Envelope glycoprotein B 1 shared papers
• Envelope glycoprotein B 1 shared papers
• Envelope glycoprotein B 1 shared papers
• Envelope glycoprotein D 1 shared papers

Literature · 9 cited papers

• Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion. Proc. Natl. Acad. Sci. U.S.A. · 2007
• Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein. J. Virol. · 2007
• Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane. Proc. Natl. Acad. Sci. U.S.A. · 2007
• Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
• The cytoplasmic tail of Herpes simplex virus glycoprotein H binds to the tegument protein VP16 in vitro and in vivo. Virology · 2003
• Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras. J. Virol. · 2003
• Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex. J. Virol. · 1998
• DNA sequence of the herpes simplex virus type 1 gene encoding glycoprotein gH, and identification of homologues in the genomes of varicella-zoster virus and Epstein-Barr virus. Nucleic Acids Res. · 1986
• The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988