Envelope glycoprotein L

Function

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.

Classification

Family (Pfam)

PF12524 GlyL_C, PF05259 Herpes_UL1

InterPro

Herpes_gL_C, Herpes_gL_N, Herpes_gL_N_sf, HSV_GL_alphagamma

Functional cluster

Membrane Translocases & Channels

Gene Ontology · 6

• GO:0044177 host cell Golgi apparatus
• GO:0020002 host cell plasma membrane
• GO:0019031 viral envelope
• GO:0055036 virion membrane
• GO:0019064 fusion of virus membrane with host plasma membrane
• GO:0046718 symbiont entry into host cell

Drugs targeting this protein · 1

• DOCOSANOL inhibitor

Related proteins · sequence + function similarity

• Envelope glycoprotein L 0.98
• Putative membrane protein insertion efficiency factor 0.66
• Envelope protein UL45 0.64
• Envelope protein UL45 0.64
• Envelope protein UL45 0.60
• Tegument protein UL51 0.58
• Movement protein TGBp3 0.58
• Putative membrane protein insertion efficiency factor 0.55
• Envelope glycoprotein L 0.55
• Movement protein TGB2 0.55
• Movement protein TGB2 0.54
• Cytochrome b559 subunit alpha 0.53

Co-cited proteins · studied together in the literature

• Envelope glycoprotein H 1 shared papers
• Envelope glycoprotein H 2 shared papers
• Envelope glycoprotein D 2 shared papers
• Envelope glycoprotein B 2 shared papers
• Tegument protein UL55 2 shared papers
• Nuclear phosphoprotein UL3 1 shared papers
• Envelope glycoprotein G 2 shared papers
• Protein UL56 1 shared papers
• Neurovirulence factor ICP34.5 1 shared papers
• ICP47 protein 1 shared papers
• mRNA export factor 1 shared papers
• Envelope glycoprotein D 1 shared papers

Literature · 9 cited papers

• Dissociation of HSV gL from gH by alphavbeta6- or alphavbeta8-integrin promotes gH activation and virus entry. Proc. Natl. Acad. Sci. U.S.A. · 2015
• HSV-1 gM and the gK/pUL20 complex are important for the localization of gD and gH/L to viral assembly sites. Viruses · 2015
• Insertional mutations in herpes simplex virus 1 gL identify functional domains for association with gH and for membrane fusion. J. Virol. · 2009
• Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain. J. Biol. Chem. · 2009
• Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. · 2008
• Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
• Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras. J. Virol. · 2003
• The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
• The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988