lmmol · Proteins

Envelope glycoprotein B

UniProt P10211 Organism Human herpesvirus 1 (strain 17) Gene gB

Also known as: gB

Function

Envelope glycoprotein that forms spikes at the surface of virion envelope and binds to the host cell entry receptors MYH9/NMMHC-IIA and MYH10/NMMHC-IIB, promoting the virus entry into host cells. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell: following initial binding to its host cell entry receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).

Classification

Family (Pfam)
PF17416 Glycoprot_B_PH1, PF17417 Glycoprot_B_PH2, PF00606 Glycoprotein_B
InterPro
Glycoprot_B_PH1, Glycoprot_B_PH2, Glycoprot_B_PH2_sf, Glycoprotein_B_ecto_C, Herpes_Glycoprot_B
Functional cluster
DNA-Directed RNA Polymerase Subunits

Experimental structures · PDB · 10

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 7 cited papers

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