Envelope glycoprotein K
Also known as: gK
Function
Glycoprotein that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation). Seems to block fusion of virions with infected-cell membranes.
Classification
- Family (Pfam)
- PF01621 Fusion_gly_K
- InterPro
- GK
- Functional cluster
- Membrane Transporters & GPCRs
Gene Ontology · 6
Drugs targeting this protein · 1
- DOCOSANOL inhibitor
Related proteins · sequence + function similarity
- Envelope glycoprotein K 1.00
- Envelope glycoprotein K 0.99
- Envelope glycoprotein K 0.97
- Envelope glycoprotein K 0.92
- Envelope glycoprotein K 0.84
- Envelope glycoprotein K 0.84
- Envelope glycoprotein K 0.81
- Envelope glycoprotein K 0.81
- Envelope glycoprotein K 0.80
- Envelope glycoprotein M 0.75
- Envelope glycoprotein K 0.73
- Glycoprotein 4 0.72
Co-cited proteins · studied together in the literature
- Envelope glycoprotein K 1 shared papers
- Protein UL20 2 shared papers
- Envelope glycoprotein B 1 shared papers
- DNA replication helicase 1 shared papers
- DNA primase 1 shared papers
- Nuclear protein UL4 1 shared papers
- DNA polymerase processivity factor 1 shared papers
- Tegument protein UL51 2 shared papers
- Envelope glycoprotein M 2 shared papers
- Replication origin-binding protein 1 shared papers
- DNA helicase/primase complex-associated protein 1 shared papers
- Portal protein 1 shared papers
Literature · 13 cited papers
- Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. · 2008
- Functional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein K. J. Virol. · 2008
- Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
- Herpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopment. J. Virol. · 2005
- Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localization. J. Virol. · 2004
- The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion. J. Virol. · 2004
- Plasma membrane topology of syncytial domains of herpes simplex virus type 1 glycoprotein K (gK): the UL20 protein enables cell surface localization of gK but not gK-mediated cell-to-cell fusion. J. Virol. · 2003
- Glycoprotein K specified by herpes simplex virus type 1 is expressed on virions as a Golgi complex-dependent glycosylated species and functions in virion entry. J. Virol. · 2001
- Determination of the transmembrane topology of herpes simplex virus type 1 glycoprotein K. J. Biol. Chem. · 1997
- Syncytial mutations in the herpes simplex virus type 1 gK (UL53) gene occur in two distinct domains. J. Virol. · 1994
- The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
- Structures of herpes simplex virus type 1 genes required for replication of virus DNA. J. Virol. · 1988
- … and 1 more in the literature graph
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