Envelope glycoprotein M
Also known as: gM
Function
Envelope glycoprotein important for virion assembly and egress. Plays a role in the correct incorporation of gH-gL into virion membrane. Directs the glycoprotein N (gN) to the host trans-Golgi network.
Classification
- Family (Pfam)
- PF01528 Herpes_glycop
- InterPro
- Herpes_glycop_M
- Functional cluster
- Membrane Transporters & GPCRs
Gene Ontology · 6
Drugs targeting this protein · 1
- DOCOSANOL inhibitor
Related proteins · sequence + function similarity
- Envelope glycoprotein M 0.95
- Envelope glycoprotein M 0.83
- Envelope glycoprotein M 0.77
- Envelope glycoprotein M 0.74
- Envelope glycoprotein M 0.71
- Envelope glycoprotein M 0.71
- Envelope glycoprotein M 0.71
- Envelope glycoprotein M 0.71
- Envelope glycoprotein M 0.70
- Envelope glycoprotein M 0.70
- Protein UL20 0.70
- Envelope glycoprotein K 0.69
Co-cited proteins · studied together in the literature
- Envelope glycoprotein N 2 shared papers
- Nuclear egress protein 2 1 shared papers
- Nuclear egress protein 1 1 shared papers
- Tegument protein UL14 1 shared papers
- Cytoplasmic envelopment protein 3 2 shared papers
- Serine/threonine-protein kinase UL13 2 shared papers
- DNA replication helicase 1 shared papers
- DNA primase 1 shared papers
- Nuclear protein UL4 1 shared papers
- Alkaline nuclease 1 shared papers
- Tripartite terminase subunit 3 1 shared papers
- DNA polymerase processivity factor 1 shared papers
Literature · 8 cited papers
- Subcellular trafficking and functional relationship of the HSV-1 glycoproteins N and M. Viruses · 2016
- The U(L)31 and U(L)34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membranes of infected cells. J. Virol. · 2009
- Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. · 2008
- Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
- Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane. J. Virol. · 2007
- DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes. Nucleic Acids Res. · 1986
- The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
- Structures of herpes simplex virus type 1 genes required for replication of virus DNA. J. Virol. · 1988
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