Envelope glycoprotein N
Also known as: gN
Function
Envelope glycoprotein necessary for proper maturation of gM and modulation of its membrane fusion activity. Also plays a critical role in virion morphogenesis.
Classification
- Family (Pfam)
- PF05702 Herpes_UL49_5
- InterPro
- GN_domain, Herpes_UL49A, HSV_GN
- Functional cluster
- Membrane Channels & Lipid-Anchored Proteins
Experimental structures · PDB · 1
- 8OSQ NMR
A predicted model is available from AlphaFold.
Gene Ontology · 4
Drugs targeting this protein · 1
- DOCOSANOL inhibitor
Related proteins · sequence + function similarity
- RBAK downstream neighbor protein 0.75
- Envelope glycoprotein J 0.69
- Putative uncharacterized protein ENSP00000380674 0.67
- Envelope glycoprotein N 0.65
- Envelope glycoprotein N 0.65
- Neuropeptide B 0.65
- Movement protein 0.65
- Small integral membrane protein 32 0.64
- TMF-regulated nuclear protein 1 0.64
- Neuropeptide B 0.63
- Uncharacterized protein FLJ37310 0.63
- Putative transmembrane protein INAFM1 0.63
Co-cited proteins · studied together in the literature
- Envelope glycoprotein N 1 shared papers
- Envelope glycoprotein M 2 shared papers
- Membrane protein UL43 1 shared papers
- Envelope protein UL45 1 shared papers
- Tegument protein UL21 1 shared papers
- Virion protein US10 1 shared papers
- Protein UL20 1 shared papers
- Envelope glycoprotein H 1 shared papers
- Tegument protein UL55 1 shared papers
- Cytoplasmic envelopment protein 3 1 shared papers
- Tegument protein UL47 1 shared papers
- Tegument protein VP16 1 shared papers
Literature · 5 cited papers
- Subcellular trafficking and functional relationship of the HSV-1 glycoproteins N and M. Viruses · 2016
- Herpes simplex virus 1 gN partners with gM to modulate the viral fusion machinery. J. Virol. · 2015
- Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. · 2008
- The carboxy-terminal domain of glycoprotein N of human cytomegalovirus is required for virion morphogenesis. J. Virol. · 2007
- The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
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