Envelope glycoprotein E
Also known as: gE
Function
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells (By similarity). In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
Classification
- Family (Pfam)
- PF02480 Herpes_gE, PF20418 Herpes_gE_N
- InterPro
- Herpes_gE_N, Herpes_glycopE_Fc, Ig-like_dom_sf, Ig-like_fold
- Functional cluster
- Secreted Growth Factors & Cytokines
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 1
- DOCOSANOL inhibitor
Related proteins · sequence + function similarity
- Envelope glycoprotein E 1.00
- Envelope glycoprotein E 0.93
- Envelope glycoprotein E 0.89
- Envelope glycoprotein I 0.83
- Envelope glycoprotein I 0.80
- Envelope glycoprotein E 0.78
- Envelope glycoprotein E 0.78
- Envelope glycoprotein E 0.78
- Envelope glycoprotein E 0.77
- Envelope glycoprotein I 0.76
- Envelope glycoprotein E 0.76
- Envelope glycoprotein C homolog 0.73
Co-cited proteins · studied together in the literature
- Envelope glycoprotein I 3 shared papers
- Tegument protein VP22 3 shared papers
- Envelope glycoprotein E 1 shared papers
- Cytoplasmic envelopment protein 3 1 shared papers
- Envelope glycoprotein D 1 shared papers
- Envelope glycoprotein D 2 shared papers
- Tegument protein VP16 1 shared papers
- Protein US2 1 shared papers
- Protein US8.5 1 shared papers
- Virion protein US10 1 shared papers
- Envelope glycoprotein J 1 shared papers
- Envelope glycoprotein G 1 shared papers
Literature · 10 cited papers
- Virion incorporation of the herpes simplex virus type 1 tegument protein VP22 occurs via glycoprotein E-specific recruitment to the late secretory pathway. J. Virol. · 2009
- Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
- Cytoplasmic residues of herpes simplex virus glycoprotein gE required for secondary envelopment and binding of tegument proteins VP22 and UL11 to gE and gD. J. Virol. · 2007
- A conserved region of the herpes simplex virus type 1 tegument protein VP22 facilitates interaction with the cytoplasmic tail of glycoprotein E (gE). Virology · 2007
- Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging. PLoS Biol. · 2006
- pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI. J. Biol. Chem. · 2004
- The C-terminal cytoplasmic tail of herpes simplex virus type 1 gE protein is phosphorylated in vivo and in vitro by cellular enzymes in the absence of other viral proteins. J. Gen. Virol. · 2000
- Processing of glycoproteins induced by herpes simplex virus type 1: sulphation and nature of the oligosaccharide linkages. J. Gen. Virol. · 1983
- Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. · 1985
- Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI. J. Virol. · 1988
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