Envelope glycoprotein I
Also known as: gI
Function
In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.
Classification
- Family (Pfam)
- PF01688 Herpes_gI
- InterPro
- Herpes_gI
- Functional cluster
- Viral Envelope Glycoproteins
Gene Ontology · 6
Drugs targeting this protein · 1
- DOCOSANOL inhibitor
Related proteins · sequence + function similarity
- Envelope glycoprotein I 0.86
- Envelope glycoprotein I 0.84
- Envelope glycoprotein E 0.76
- Envelope glycoprotein E 0.76
- Envelope glycoprotein E 0.73
- Envelope glycoprotein I 0.70
- Envelope glycoprotein I 0.70
- Envelope glycoprotein I 0.70
- Envelope glycoprotein D 0.70
- Envelope glycoprotein D 0.70
- Envelope glycoprotein G 0.70
- Envelope glycoprotein G 0.70
Co-cited proteins · studied together in the literature
- Envelope glycoprotein E 4 shared papers
- Envelope glycoprotein E 3 shared papers
- Protein US2 1 shared papers
- Protein US8.5 1 shared papers
- Envelope glycoprotein J 2 shared papers
- Envelope glycoprotein G 2 shared papers
- Envelope protein US9 2 shared papers
- Virion protein US10 1 shared papers
- Membrane protein UL43 1 shared papers
- Envelope protein UL45 1 shared papers
- Tegument protein UL21 1 shared papers
- Virion protein US10 1 shared papers
Literature · 7 cited papers
- Comprehensive characterization of extracellular herpes simplex virus type 1 virions. J. Virol. · 2008
- Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
- Herpes simplex virus gE/gI must accumulate in the trans-Golgi network at early times and then redistribute to cell junctions to promote cell-cell spread. J. Virol. · 2006
- pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI. J. Biol. Chem. · 2004
- Herpes simplex virus gE/gI sorts nascent virions to epithelial cell junctions, promoting virus spread. J. Virol. · 2001
- Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. · 1985
- Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gI. J. Virol. · 1988
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