Cyclin-dependent kinase 18

Function

May play a role in signal transduction cascades in terminally differentiated cells.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Gene Ontology · 9

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0031643 positive regulation of myelination
• GO:1901987 regulation of cell cycle phase transition

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 18 1.00
• Cyclin-dependent kinase 18 0.96
• Cyclin-dependent kinase 18 0.95
• Cyclin-dependent kinase 17 0.90
• Cyclin-dependent kinase 14 0.89
• Cyclin-dependent kinase 14 0.89
• Cyclin-dependent kinase 17 0.89
• Cyclin-dependent kinase 14 0.89
• Cyclin-dependent kinase 15 0.89
• Cyclin-dependent kinase 17 0.89
• Cyclin-dependent kinase 14 0.89
• Cyclin-dependent kinase 14 0.88

Co-cited proteins · studied together in the literature

• Cyclin-dependent kinase 17 1 shared papers
• Cyclin-dependent kinase-like 1 1 shared papers
• Cyclin-dependent kinase 3 1 shared papers
• Cyclin-dependent kinase 16 1 shared papers
• Cyclin-dependent kinase 6 1 shared papers
• Cyclin-dependent kinase 5 1 shared papers

Literature · 11 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. Gene · 2004
• A family of human cdc2-related protein kinases. EMBO J. · 1992