Cyclin-dependent kinase 3

Function

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Experimental structures · PDB · 2

• 7XQK X-ray 2.25A
• 8H4R X-ray 2.75A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005737 cytoplasm
• GO:0005634 nucleus
• GO:0005524 ATP binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0051301 cell division
• GO:0008283 cell population proliferation
• GO:0006974 DNA damage response
• GO:0045023 G0 to G1 transition
• GO:0000082 G1/S transition of mitotic cell cycle
• GO:0000086 G2/M transition of mitotic cell cycle
• GO:0045746 negative regulation of Notch signaling pathway
• GO:0007165 signal transduction

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 2 0.97
• Cyclin-dependent kinase 3 0.96
• Cyclin-dependent kinase 2 0.96
• Cyclin-dependent kinase A-1 0.96
• Cell division control protein 2 homolog 0.95
• Cyclin-dependent kinase 1 0.95
• Cyclin-dependent kinase 1 0.95

Co-cited proteins · studied together in the literature

• Cyclic AMP-dependent transcription factor ATF-1 1 shared papers
• Cyclin-dependent kinase 17 1 shared papers
• Cyclin-dependent kinase 18 1 shared papers
• Retinoblastoma-associated protein 1 shared papers
• Cyclin-dependent kinase-like 1 1 shared papers
• Cyclin-dependent kinase 16 1 shared papers
• Cyclin-dependent kinase 6 1 shared papers
• Cyclin-dependent kinase 5 1 shared papers

Literature · 5 cited papers

• Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. Cancer Res. · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell · 2004
• Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. Genes Dev. · 1996
• A family of human cdc2-related protein kinases. EMBO J. · 1992