Cyclin-dependent kinase 16

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CDK, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Serine/Threonine Protein Kinases

Experimental structures · PDB · 2

• 3MTL X-ray 2.40A
• 5G6V X-ray 2.20A

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0000307 cyclin-dependent protein kinase holoenzyme complex
• GO:0005737 cytoplasm
• GO:0009898 cytoplasmic side of plasma membrane
• GO:0005829 cytosol
• GO:0043005 neuron projection
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0008021 synaptic vesicle
• GO:0005524 ATP binding
• GO:0004693 cyclin-dependent protein serine/threonine kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0006887 exocytosis
• GO:0030252 growth hormone secretion
• GO:0031175 neuron projection development
• GO:0010508 positive regulation of autophagy
• GO:0006468 protein phosphorylation
• GO:1901987 regulation of cell cycle phase transition
• GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
• GO:0007283 spermatogenesis

Drugs targeting this protein · 4

• PHA-793887 inhibitor
• RONICICLIB inhibitor
• AT-7519 inhibitor
• AZD-5438 inhibitor

Related proteins · sequence + function similarity

• Cyclin-dependent kinase 16 0.99
• Cyclin-dependent kinase 16 0.98
• Cyclin-dependent kinase 17 0.92
• Cyclin-dependent kinase 17 0.92
• Cyclin-dependent kinase 18 0.91
• Cyclin-dependent kinase 17 0.91
• Cyclin-dependent kinase 18 0.90
• Cyclin-dependent kinase 18 0.89
• Cyclin-dependent kinase 18 0.88
• Cyclin-dependent kinase 14 0.85
• Cyclin-dependent kinase 14 0.85
• Cyclin-dependent kinase 14 0.85

Co-cited proteins · studied together in the literature

• Cyclin-dependent kinase 16 3 shared papers
• Cyclin-Y 1 shared papers
• Cyclin-Y-like protein 1 1 shared papers
• Cyclin-dependent kinase 17 1 shared papers
• Cyclin-dependent kinase 18 1 shared papers
• Serine/threonine-protein kinase BRSK2 1 shared papers
• Cyclin-Y 1 shared papers
• Serine/threonine-protein kinase BRSK2 1 shared papers
• Cyclin-dependent kinase-like 1 1 shared papers
• Cyclin-dependent kinase 3 1 shared papers
• Cyclin-dependent kinase 6 1 shared papers
• Cyclin-dependent kinase 5 1 shared papers

Literature · 15 cited papers

• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. J. Biol. Chem. · 2012
• Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. Cell. Signal. · 2012
• Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis. Mol. Cell. Biol. · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
• The DNA sequence of the human X chromosome. Nature · 2005
• … and 3 more in the literature graph